Rabbit Polyclonal CLINT1 Antibody

The CLINT1 (Clathrin Interactor 1) antibody is a tool used to study the CLINT1 protein, also known as EpsinR (Epsin-related protein), which plays a critical role in intracellular membrane trafficking. CLINT1 contains an N-terminal ENTH (epsin N-terminal homology) domain that binds phosphatidylinositol lipids and a C-terminal region interacting with clathrin and adaptor protein complexes (AP-1/AP-2). This protein facilitates clathrin-mediated endocytosis and vesicle transport between the trans-Golgi network (TGN) and endosomes. Researchers use CLINT1 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interaction partners in cellular trafficking pathways. Studies implicate CLINT1 in synaptic vesicle recycling, receptor internalization, and cargo sorting, with potential links to neurological disorders and cancer. The antibody’s specificity enables exploration of CLINT1’s regulatory mechanisms in membrane dynamics, making it valuable for understanding vesicular transport pathologies. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal) vary across commercial antibodies, requiring validation for experimental contexts.