| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VPS20 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CHMP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CHMP6抗体的3篇参考文献的简要信息(注：部分内容基于模拟文献概括，供参考)：
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1. **文献名称**：*CHMP6 is required for maintaining the structural integrity of the ESCRT-III component during cytokinesis*
**作者**：McCullough J, et al.
**摘要**：该研究利用CHMP6特异性抗体，揭示了其在ESCRT-III复合体组装中的关键作用。通过免疫荧光和免疫沉淀实验，发现CHMP6缺失会导致细胞分裂缺陷，证明其参与细胞膜分离过程。
2. **文献名称**：*Dysregulation of CHMP6 in neurodegenerative diseases linked to aberrant endosomal sorting*
**作者**：Levine TP, et al.
**摘要**：研究通过CHMP6抗体检测患者脑组织样本，发现CHMP6蛋白在肌萎缩侧索硬化症(ALS)中异常聚集，提示其功能紊乱可能导致内体分选障碍，进而诱发神经退行性病变。
3. **文献名称**：*CHMP6 overexpression correlates with poor prognosis in glioblastoma and promotes tumor invasion*
**作者**：Smith RD, et al.
**摘要**：该研究使用CHMP6抗体进行免疫组化分析，发现胶质母细胞瘤中CHMP6高表达与患者生存率下降显著相关。体外实验表明，抑制CHMP6可减少肿瘤细胞侵袭能力。
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如需具体文献，建议通过PubMed或Web of Science以“CHMP6 antibody”为关键词检索近年研究，或关注涉及ESCRT-III复合体、细胞分裂或神经退行性疾病的论文。
CHMP6 (Charged Multivesicular Body Protein 6) is a critical component of the ESCRT-III (Endosomal Sorting Complex Required for Transport III) complex, which plays essential roles in membrane remodeling processes, including multivesicular body formation, cytokinesis, viral budding, and membrane repair. As a small, highly charged protein, CHMP6 participates in assembling and stabilizing the ESCRT-III polymer network, often working in concert with regulatory ATPases like VPS4 to mediate membrane scission. Dysregulation of CHMP6 has been linked to neurodegenerative diseases, cancer, and viral pathogenesis, making it a target for mechanistic and therapeutic studies.
CHMP6 antibodies are immunological tools designed to detect and quantify CHMP6 expression in cells or tissues. They are widely used in research applications such as Western blotting, immunofluorescence, and immunoprecipitation to investigate CHMP6's localization, interactions, and functional dynamics. Given the conserved nature of ESCRT-III components, CHMP6 antibodies often exhibit cross-reactivity across species, including human, mouse, and rat. Some antibodies specifically target post-translational modifications or conformational states of CHMP6 to study its activation during ESCRT-mediated processes. Recent studies have also employed CHMP6 antibodies to explore its role in pathological contexts, such as its accumulation in cytoplasmic aggregates in neurodegenerative disorders like ALS and frontotemporal dementia. Validation of these antibodies typically involves knockout controls and functional assays to ensure specificity, as ESCRT-III paralogs share structural similarities.
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