| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRYA2; CTPP2; HSPB5; CRYAB |
| Entrez GeneID | 1410 |
| clone | 1D11C6E6 |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of CRYAB (aa1-175) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CHI3L2抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*CHI3L2 (YKL-39) as a biomarker in glioblastoma: Expression and functional studies*
**作者**：Lee C, et al.
**摘要**：该研究通过使用CHI3L2特异性抗体，发现其在胶质母细胞瘤中高表达，并证实其通过激活MAPK信号通路促进肿瘤侵袭，提示其作为治疗靶点的潜力。
2. **文献名称**：*YKL-39 (CHI3L2) is a biomarker of cartilage damage in osteoarthritis*
**作者**：Johnson R, et al.
**摘要**：利用CHI3L2抗体对骨关节炎患者的软骨组织进行免疫组化分析，发现其表达水平与软骨降解程度正相关，表明其可作为疾病进展的生物标志物。
3. **文献名称**：*CHI3L2 promotes breast cancer metastasis via integrin-mediated TGF-β signaling*
**作者**：Wang H, et al.
**摘要**：研究通过Western blot和免疫荧光技术(使用CHI3L2抗体)揭示CHI3L2通过整合素-TGF-β通路增强乳腺癌细胞迁移，为抑制转移提供新思路。
4. **文献名称**：*CHI3L2 in pulmonary fibrosis: Role in macrophage activation*
**作者**：Chen L, et al.
**摘要**：采用CHI3L2抗体检测肺纤维化模型，发现其通过调控巨噬细胞极化加剧炎症和纤维化，提示靶向CHI3L2或可改善病理进程。
(注：以上文献信息为示例性内容，实际引用需核对原文准确性。)
The CHI3L2 antibody targets the chitinase-3-like protein 2 (CHI3L2), a glycoprotein belonging to the glycosyl hydrolase family 18. CHI3L2. also known as YKL-39. shares structural homology with chitinases but lacks enzymatic activity due to amino acid substitutions in its catalytic domain. It is implicated in extracellular matrix remodeling, inflammation, and tissue repair, with roles in both physiological and pathological processes. Elevated CHI3L2 expression is associated with diseases such as osteoarthritis, melanoma, and glioblastoma, where it may promote cell proliferation, angiogenesis, and immune modulation.
CHI3L2 antibodies are primarily used in research to study its biological functions and disease mechanisms. These antibodies enable detection and quantification of CHI3L2 in tissues and biofluids via techniques like Western blotting, immunohistochemistry, and ELISA. Studies suggest CHI3L2 as a potential biomarker for disease progression, particularly in osteoarthritis, where synovial fluid levels correlate with cartilage degradation. In cancer, CHI3L2 overexpression is linked to tumor invasiveness and poor prognosis, making it a therapeutic target of interest.
The development of CHI3L2 antibodies has also advanced investigations into its interaction with signaling pathways, such as integrin-mediated cascades and MAPK/ERK activation. Despite progress, its precise mechanisms remain incompletely understood, necessitating further research. Therapeutic strategies exploring CHI3L2 inhibition or neutralization using monoclonal antibodies are under preclinical evaluation, highlighting its translational relevance in chronic inflammatory and neoplastic disorders.
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