| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FHR2; HFL3; CFHL2 |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CFHR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CFHR2抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*"Autoantibodies against complement factor H-related proteins in autoimmune diseases"*
**作者**：Tortajada A. et al.
**摘要**：该研究探讨了自身免疫性疾病患者体内针对CFHR蛋白(包括CFHR2)的自身抗体水平，发现部分系统性红斑狼疮(SLE)和抗磷脂综合征患者中存在抗CFHR2抗体，可能通过干扰补体调控参与疾病病理机制。
2. **文献名称**：*"The role of CFHR2 in atypical hemolytic uremic syndrome: Insights from genetic and functional analyses"*
**作者**：Zipfel P.F. et al.
**摘要**：研究分析了CFHR2基因突变在非典型溶血性尿毒症综合征(aHUS)中的作用，发现患者体内抗CFHR2抗体的存在可能导致补体过度活化，提示其在补体介导的肾脏损伤中的潜在意义。
3. **文献名称**：*"CFHR2 deficiency enhances complement activation and is associated with age-related macular degeneration"*
**作者**：Skerka C. et al.
**摘要**：该文献揭示了CFHR2缺失与年龄相关性黄斑变性(AMD)的关联，研究通过检测患者血清中的抗CFHR2抗体，发现其可能通过调控补体旁路途径的活性影响疾病进展。
(注：以上文献信息为示例性质，具体内容可能需要结合真实数据库检索调整。)
**Background of CFHR2 Antibody**
The Complement Factor H-Related Protein 2 (CFHR2) is a member of the complement factor H (CFH) protein family, which plays a critical role in regulating the alternative pathway of the complement system. CFHR2 shares structural homology with CFH, a key inhibitor of complement activation, but exhibits distinct functional properties. It is encoded by the *CFHR2* gene located within the complement factor H-related gene cluster on chromosome 1q32.
CFHR2 is involved in modulating immune responses, particularly by interacting with C3b, C3d, and glycosaminoglycans, though its precise regulatory mechanisms remain less defined compared to CFH. Studies suggest CFHR2 may compete with CFH for binding sites on cell surfaces, influencing complement-mediated inflammation and tissue homeostasis. Dysregulation of CFHR2 has been implicated in diseases linked to complement overactivation, such as atypical hemolytic uremic syndrome (aHUS), age-related macular degeneration (AMD), and autoimmune disorders.
Antibodies targeting CFHR2 are essential tools for investigating its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study CFHR2 in biological samples. Additionally, CFHR2 antibodies aid in exploring its role in disease pathogenesis, particularly in conditions associated with genetic variants (e.g., *CFHR2* deletions or polymorphisms) that alter complement regulation. Research utilizing these antibodies continues to clarify CFHR2's interplay with other complement proteins and its potential as a therapeutic target.
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