| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | T3G; IMD17; CD3-GAMMA |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CD3G |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CD3G抗体的示例参考文献(内容为示例性质，非真实文献)：
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1. **文献名称**: "Structural Insights into CD3γ Subunit in T Cell Receptor Signaling"
**作者**: Smith A, et al.
**摘要**: 研究利用X射线晶体学解析了CD3G蛋白的分子结构，揭示了其与TCR复合物中其他亚基(如CD3ε和CD3δ)的相互作用机制，为T细胞信号转导的分子基础提供了新见解。
2. **文献名称**: "CD3G Antibody-Based Modulation of T Cell Activation in Autoimmune Diseases"
**作者**: Johnson R, et al.
**摘要**: 通过体外实验证明，靶向CD3G的单克隆抗体可选择性抑制过度活跃的T细胞活化，在类风湿性关节炎小鼠模型中减轻炎症反应，提示其作为自身免疫疾病治疗策略的潜力。
3. **文献名称**: "CD3G Expression Correlates with T Cell Exhaustion in Chronic Viral Infections"
**作者**: Lee H, et al.
**摘要**: 分析HIV感染者外周血T细胞发现，CD3G表达水平与T细胞耗竭标志物(如PD-1)呈负相关，表明CD3G下调可能参与慢性感染中的免疫逃逸机制。
4. **文献名称**: "Development of a Novel Anti-CD3G CAR-T Cell Therapy for Solid Tumors"
**作者**: Wang Y, et al.
**摘要**: 研究设计了一种基于CD3G抗体的嵌合抗原受体(CAR)，在体外和动物模型中验证了其对实体瘤细胞的靶向杀伤效果，为增强CAR-T疗法特异性提供了新方向。
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如需真实文献，建议通过PubMed、Web of Science或Google Scholar检索关键词“CD3G antibody”“CD3 gamma T cell”等，并筛选近年的高影响力研究。
CD3G (CD3 gamma) is a subunit of the CD3 complex, a critical component of the T-cell receptor (TCR) signaling apparatus in T lymphocytes. The CD3 complex consists of γ, δ, ε, and ζ chains, which associate with the TCR to form a functional receptor complex. CD3G, encoded by the CD3G gene, is a transmembrane protein with an extracellular immunoglobulin-like domain, a transmembrane region, and a cytoplasmic tail containing immunoreceptor tyrosine-based activation motifs (ITAMs). These ITAMs are essential for propagating intracellular signals upon TCR engagement with antigens presented by MHC molecules.
CD3G antibodies are tools used to detect or modulate this subunit. They play a key role in research applications, including flow cytometry, immunohistochemistry, and Western blotting, to identify T-cell populations or assess CD3 expression in immune disorders. Therapeutic CD3G-targeting antibodies are explored in immunotherapy, particularly in redirecting T-cell activity against cancer or autoimmune cells. For instance, bispecific antibodies binding CD3G and tumor antigens can engage T cells to attack malignancies.
Mutations in CD3G are linked to severe immune deficiencies, such as CD3γ-deficient severe combined immunodeficiency (SCID), underscoring its role in T-cell development. Studies using CD3G antibodies have advanced understanding of TCR signaling dynamics, immune tolerance, and pathologies like autoimmune diseases or lymphomas. Their specificity makes them invaluable in both diagnostics and experimental models of T-cell-mediated immunity.
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