| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | OSM; C7orf22; PP10187 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CCM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3条关于CCM2抗体的参考文献示例，包含文献名称、作者及摘要概括：
---
1. **文献名称**：*"CCM2 Antibody Characterization in Cerebral Cavernous Malformation Pathogenesis"*
**作者**：Zhang Y, et al.
**摘要**：本研究利用特异性CCM2抗体，通过免疫印迹和免疫荧光技术，验证了CCM2蛋白在血管内皮细胞中的表达缺失与血窦结构异常的关联，揭示了CCM2通过调控RhoA/ROCK信号通路维持血管稳定性。
2. **文献名称**：*"Development of a Novel Monoclonal Antibody for CCM2 Detection in Human Tissue Samples"*
**作者**：Müller S, et al.
**摘要**：作者团队开发了一种高特异性抗CCM2单克隆抗体，并应用于人脑组织切片的免疫组化分析，发现CCM2蛋白表达水平与血管畸形严重程度呈负相关，为临床诊断提供了新工具。
3. **文献名称**：*"CCM2-KRIT1 Interaction Revealed by Co-Immunoprecipitation Using CCM2-Specific Antibodies"*
**作者**：Bravi L, et al.
**摘要**：通过CCM2抗体进行免疫共沉淀实验，证实了CCM2与KRIT1(CCM1)在血管内皮细胞中的直接互作，并证明该复合物对维持血管内皮屏障功能至关重要，缺陷将导致渗漏性增加。
---
以上示例综合了CCM2抗体的基础研究、诊断工具开发及分子机制探索，涵盖不同应用场景及研究目标。如需真实文献，建议通过PubMed或Web of Science检索具体关键词(如“CCM2 antibody”、“CCM2 detection”)。
The CCM2 (cerebral cavernous malformation 2) antibody is a key tool for studying the CCM2 protein, which plays a critical role in vascular development and homeostasis. CCM2. encoded by the CCM2 gene (also known as OSM or MGC4607), forms a ternary complex with KRIT1 (CCM1) and PDCD10 (CCM3) to regulate endothelial cell signaling, angiogenesis, and vascular integrity. This complex primarily modulates the MEKK3–KLF2/4 signaling pathway, influencing cell adhesion, apoptosis, and endothelial barrier function. Mutations in CCM2 are linked to cerebral cavernous malformations (CCMs), vascular lesions in the central nervous system that predispose individuals to seizures, hemorrhages, and neurological deficits.
CCM2 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate CCM2's interaction networks, subcellular localization, and dysregulation in disease models. Additionally, these antibodies aid in investigating molecular mechanisms underlying CCM pathogenesis, such as disrupted Rho GTPase signaling or hyperpermeable vasculature. Commercial CCM2 antibodies are typically validated for specificity in human, mouse, or rat tissues, supporting translational studies aiming to develop targeted therapies for CCMs. Their application extends to screening genetic mutations and evaluating therapeutic interventions in preclinical studies.
×
