Rabbit Polyclonal ZUP1 Antibody

The ZUP1 antibody is a research tool designed to target the ZUP1 protein, a critical player in cellular processes such as DNA damage response and genome maintenance. ZUP1 (also known as ZNF862 or C6orf142) is a zinc finger-containing protein implicated in ubiquitination pathways, interacting with E3 ligase complexes to regulate protein degradation and signaling. Studies suggest its involvement in resolving DNA-protein crosslinks (DPCs), a type of DNA lesion that obstructs replication and transcription, by coordinating repair mechanisms with factors like SPRTN and the ATM/ATR kinases. Dysregulation of ZUP1 is linked to genomic instability and diseases, including cancer and neurodegenerative disorders. The ZUP1 antibody, typically developed in rabbit or mouse models, enables detection and analysis of ZUP1 expression and localization via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its applications span basic research on DNA repair mechanisms, biomarker studies in cancer, and drug development targeting genome stability pathways. Commercial versions are available from suppliers such as Abcam and Novus Biologicals, with validation data supporting specificity across human and rodent samples. This antibody serves as a vital resource for elucidating ZUP1's molecular functions and therapeutic potential.