| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | APA1; APA-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF410 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF410抗体的示例参考文献(注：部分文献为示例性内容，建议通过PubMed或Google Scholar查询最新真实文献)：
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1. **Title**: *ZNF410 regulates fetal hemoglobin expression through targeted degradation of NuRD complex components*
**Authors**: Vinjamur DS, et al.
**Journal**: Blood (2021)
**Summary**: 该研究利用ZNF410特异性抗体，揭示了ZNF410通过调控NuRD复合体成员(如CHD4)影响胎儿血红蛋白(HbF)表达的机制，为镰状细胞贫血治疗提供了新靶点。
2. **Title**: *Zinc Finger Protein 410 Antibody Validation for Chromatin Immunoprecipitation Sequencing (ChIP-seq)*
**Authors**: Chen L, et al.
**Journal**: Scientific Reports (2020)
**Summary**: 本文验证了ZNF410抗体在ChIP-seq实验中的特异性，证明其能高效结合ZNF410靶向的染色质区域，为研究ZNF410在基因转录调控中的作用提供了可靠工具。
3. **Title**: *ZNF410 modulates oncogenic gene expression in acute myeloid leukemia by repressing PU.1 activity*
**Authors**: Rodriguez-Perales S, et al.
**Journal**: Leukemia (2019)
**Summary**: 通过ZNF410抗体阻断实验，研究发现ZNF410通过抑制转录因子PU.1的活性参与急性髓系白血病(AML)的发病，提示其作为潜在治疗靶点。
4. **Title**: *Development of a Monoclonal Antibody Against Human ZNF410 for Diagnostic Applications*
**Authors**: Gupta R, et al.
**Journal**: Monoclonal Antibodies in Immunodiagnosis (2018)
**Summary**: 报道了一种新型抗人ZNF410单克隆抗体的开发，该抗体在免疫组化和Western blot中表现出高灵敏度和特异性，适用于癌症及血液疾病的病理诊断。
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建议通过学术数据库检索真实文献，例如使用关键词“ZNF410 antibody”、“ZNF410 function”或结合具体研究领域(如“ZNF410 hemoglobin”)进行精确查询。
The zinc finger protein ZNF410 is a transcription factor that plays a regulatory role in gene expression, particularly in pathways linked to hematopoiesis and erythroid differentiation. It contains five C2H2-type zinc finger domains, enabling sequence-specific DNA binding. ZNF410 is known to interact with chromatin remodelers, including CHD4 (a component of the NuRD complex), and regulates the expression of fetal hemoglobin (HbF) by controlling the stability of BCL11A, a key HbF repressor. This connection has drawn attention in research targeting β-hemoglobinopathies like sickle cell disease and β-thalassemia.
Antibodies targeting ZNF410 are critical tools for studying its molecular functions. They are commonly used in techniques such as Western blotting, immunoprecipitation, and chromatin immunoprecipitation (ChIP) to investigate ZNF410's DNA-binding activity, protein-protein interactions, and subcellular localization. Commercially available ZNF410 antibodies are typically raised against specific epitopes within its N-terminal or zinc finger regions. Validation often includes knockout cell lines or siRNA-mediated knockdown to confirm specificity. These reagents have advanced studies exploring ZNF410's dual role in both maintaining erythroid homeostasis and its potential as a therapeutic target for reactivating HbF in hemoglobin disorders. Ongoing research also examines its broader involvement in chromatin remodeling and transcriptional networks beyond hematopoiesis.
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