| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JAZ; Zfp346 |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF346抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *ZNF346 interacts with hnRNP-U and contributes to paraspeckle formation*
**作者**: Wang Y, et al.
**摘要**: 研究揭示了ZNF346蛋白通过与核内RNA结合蛋白hnRNP-U相互作用，参与调控核旁斑(paraspeckles)的形成。文中提到使用特异性ZNF346抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，证实其在亚细胞定位中的功能。
2. **文献名称**: *ZNF346 knockdown induces apoptosis in cancer cells through p53 activation*
**作者**: Li H, et al.
**摘要**: 本研究通过RNA干扰和ZNF346抗体Western blot验证，发现ZNF346基因沉默可激活p53通路，导致癌细胞凋亡，提示其作为潜在肿瘤治疗靶点的价值。
3. **文献名称**: *Characterization of a novel polyclonal antibody against human ZNF346*
**作者**: Zhang R, et al.
**摘要**: 文章报道了一种新型兔源多克隆抗体的开发，通过重组ZNF346蛋白免疫动物制备。该抗体在ELISA、免疫组化和流式细胞术中表现出高特异性和灵敏度，适用于多种实验体系。
(注：以上文献为模拟示例，实际文献需通过PubMed或Google Scholar检索确认。)
ZNF346 antibody is a research tool designed to detect and study the zinc finger protein 346 (ZNF346), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF346. also known as JAZ or ZSCAN42. is encoded by the *ZNF346* gene in humans and is implicated in transcriptional regulation and RNA metabolism. Structurally, it contains multiple C2H2-type zinc finger motifs, which enable sequence-specific DNA or RNA binding, and a KRAB domain that often mediates interactions with co-repressors to regulate gene silencing.
Studies suggest ZNF346 plays roles in cellular stress responses, apoptosis, and cancer progression. For example, it has been linked to modulating p53-dependent apoptotic pathways under oxidative stress and may act as a tumor suppressor in certain cancers. Dysregulation of ZNF346 expression has been observed in malignancies like hepatocellular carcinoma and glioblastoma.
The ZNF346 antibody is typically generated using recombinant protein fragments or synthetic peptides corresponding to specific epitopes of the human ZNF346 protein. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate ZNF346's expression patterns, subcellular localization (primarily nuclear), and interactions with other biomolecules. Validated antibodies are essential for exploring ZNF346's functional mechanisms, its involvement in disease pathways, and potential therapeutic applications. Researchers rely on these antibodies to dissect its role in gene regulation, RNA processing, and cellular homeostasis across normal and pathological conditions.
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