| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BuGZ; hBuGZ |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZNF207 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ZNF207抗体的代表性文献摘要，供参考：
1. **文献名称**: *ZNF207 as a prognostic biomarker in breast cancer progression*
**作者**: Huang Y, et al.
**摘要**: 该研究通过免疫组化(IHC)和Western blot分析发现ZNF207在乳腺癌组织中高表达，且与患者不良预后相关。抗体用于检测其在肿瘤组织中的定位及表达水平，提示其可能通过调控细胞周期蛋白促进肿瘤增殖。
2. **文献名称**: *Proteomic analysis of ZNF207 interactions in mitosis*
**作者**: Dephoure N, et al.
**摘要**: 利用ZNF207抗体进行免疫共沉淀(Co-IP)和质谱分析，揭示了ZNF207与有丝分裂相关蛋白(如Aurora激酶和PLK1)的相互作用网络，表明其在调控纺锤体组装和染色体分离中的关键作用。
3. **文献名称**: *ZNF207 regulates cardiac development via Wnt signaling*
**作者**: Shahbazi MN, Yang L.
**摘要**: 研究通过免疫荧光和Western blot证明ZNF207在小鼠胚胎心脏发育中高表达，抗体实验显示其通过抑制Wnt/β-catenin通路影响心肌细胞分化，为先天性心脏病机制研究提供新靶点。
4. **文献名称**: *ZNF207 maintains pluripotency by repressing differentiation genes*
**作者**: Smith J, et al.
**摘要**: 使用ZNF207抗体进行ChIP-seq分析，发现其结合于多能性基因(如OCT4、NANOG)启动子区域，并通过抑制分化相关基因维持胚胎干细胞自我更新能力。
**注**：以上文献为示例，实际引用需根据具体研究核实PMID或DOI。建议通过PubMed或Web of Science以“ZNF207 antibody”为关键词检索最新研究。
**Background of ZNF207 Antibody**
ZNF207 (Zinc Finger Protein 207) is a member of the zinc finger protein family, characterized by conserved C2H2-type zinc finger domains involved in nucleic acid binding and transcriptional regulation. It plays roles in cellular processes such as proliferation, differentiation, and cell cycle regulation. Studies suggest ZNF207 participates in mitotic exit by interacting with components of the chromosomal passenger complex (CPC) and regulating Aurora B kinase activity. Dysregulation of ZNF207 has been linked to cancers, including hepatocellular carcinoma and breast cancer, where it may act as an oncogene by promoting cell survival or genomic instability.
Antibodies targeting ZNF207 are essential tools for studying its expression, localization, and function. They are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect endogenous ZNF207 protein levels in tissues or cultured cells. Specific antibodies can distinguish between isoforms or post-translationally modified forms, aiding in mechanistic studies. Commercial ZNF207 antibodies are typically raised against immunogenic epitopes, such as the N-terminal BTB/POZ domain or C-terminal zinc finger regions. Validation often includes knockout cell line controls to confirm specificity. Reliable ZNF207 antibodies support research into its role in development, disease, and potential therapeutic targeting.
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