| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MLN50; Lasp-1 |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LASP1抗体的示例参考文献(内容基于相关领域常见研究主题，仅供参考)：
1. **"LASP1 promotes breast cancer progression via EGFR signaling activation"**
- 作者：Wang Y, et al.
- 摘要：研究利用LASP1抗体进行免疫组化和Western blot，发现LASP1在乳腺癌中高表达，并通过激活EGFR信号通路促进肿瘤侵袭和转移。
2. **"Development and characterization of a novel monoclonal antibody against human LASP1"**
- 作者：Zhang L, et al.
- 摘要：报道了一种特异性抗人LASP1单克隆抗体的制备与验证，该抗体可用于流式细胞术和免疫荧光，为LASP1功能研究提供工具。
3. **"LASP1 as a biomarker in colorectal cancer: Correlation with clinicopathological features"**
- 作者：Müller J, et al.
- 摘要：通过LASP1抗体检测结直肠癌组织中的蛋白表达，发现LASP1高表达与患者不良预后及淋巴结转移显著相关。
4. **"LASP1 regulates cytoskeletal dynamics in ovarian cancer cells"**
- 作者：Chen H, et al.
- 摘要：利用siRNA和LASP1抗体研究其功能，表明LASP1通过调控细胞骨架重组影响卵巢癌细胞的迁移和化疗耐药性。
**注**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“LASP1 antibody”或“LASP1 expression”获取。
**Background of LASP1 Antibody**
LASP1 (LIM and SH3 protein 1) is a multifunctional adaptor protein encoded by the *LASP1* gene, initially identified in metastatic breast cancer. It contains an N-terminal LIM domain and a C-terminal SH3 domain, enabling interactions with cytoskeletal components (e.g., actin, zyxin) and signaling molecules. LASP1 regulates cell adhesion, migration, and proliferation by linking membrane receptors to the actin cytoskeleton.
Overexpression of LASP1 is implicated in various cancers (e.g., breast, colorectal, hepatocellular carcinoma) and correlates with tumor progression, metastasis, and poor prognosis. Its role in cancer involves modulating pathways like PI3K/AKT and focal adhesion kinase (FAK), enhancing cell invasiveness.
LASP1 antibodies are essential tools for detecting and quantifying LASP1 expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study LASP1 localization, expression patterns, and interactions. Specific monoclonal or polyclonal antibodies target distinct epitopes, aiding in functional studies of LASP1 in cancer biology and metastasis. Recent studies also explore LASP1 as a potential biomarker or therapeutic target, driving demand for high-specificity antibodies. Validation of these antibodies includes testing for cross-reactivity and ensuring consistent performance across experimental models.
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