| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human UGT3A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UGT3A1抗体的3篇文献信息(注：因该基因研究相对较少，部分文献为假设性示例，建议通过学术数据库核实)：
1. **文献名称**：Characterization of UGT3A1-specific monoclonal antibody and its tissue distribution
**作者**：Smith J, et al.
**摘要**：本研究开发了一种针对UGT3A1蛋白的单克隆抗体，并通过Western blot和免疫组化验证其特异性。结果显示，UGT3A1在肝脏和肾脏中高表达，可能参与类固醇代谢的葡萄糖醛酸化过程。
2. **文献名称**：Functional analysis of UGT3A1 polymorphisms using a novel polyclonal antibody
**作者**：Chen L, et al.
**摘要**：研究团队制备了兔源多克隆抗体，用于检测UGT3A1在不同人群中的蛋白表达差异。实验发现特定基因突变会导致UGT3A1酶活性降低，可能与个体化药物代谢差异相关。
3. **文献名称**：UGT3A1 expression in human cancers: An immunohistochemical study
**作者**：Wang Y, et al.
**摘要**：利用商业化UGT3A1抗体分析多种肿瘤组织样本，发现其在结直肠癌中表达显著上调，提示UGT3A1可能在癌细胞解毒途径中发挥潜在作用。
注：上述文献为模拟示例，实际研究中UGT3A1相关抗体文献较少，建议通过PubMed或Google Scholar以关键词“UGT3A1 antibody”或“UGT3A1 immunohistochemistry”检索最新数据。
The UGT3A1 antibody is a tool used to study the UDP-glucuronosyltransferase 3A1 (UGT3A1) enzyme, a member of the glycosyltransferase family. UGT3A1 catalyzes the transfer of glycosyl groups, particularly utilizing UDP-N-acetylglucosamine (UDP-GlcNAc) as a sugar donor, distinguishing it from other UGT isoforms that primarily use UDP-glucuronic acid. This enzyme plays a role in conjugating small lipophilic molecules, such as steroids, bile acids, and xenobiotics, enhancing their solubility for excretion. UGT3A1 is expressed in various tissues, including the liver, kidneys, and gastrointestinal tract, though its expression levels and substrate specificity remain less characterized compared to UGT1 and UGT2 families.
Antibodies targeting UGT3A1 are essential for investigating its tissue distribution, protein expression patterns, and functional roles in metabolism and detoxification. They are widely employed in techniques like Western blotting, immunohistochemistry, and enzyme activity assays. Research involving UGT3A1 antibodies has gained interest in understanding its potential implications in diseases such as cancer, metabolic disorders, or drug resistance, where altered glycosylation processes may contribute to pathogenesis. However, challenges persist in developing highly specific antibodies due to sequence homology among UGT family members. Validated UGT3A1 antibodies are critical for elucidating its biological significance and therapeutic potential in precision medicine.
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