| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NIAM; TB-5 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TBRG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TBRG1抗体的示例参考文献(注：部分内容为假设性概括，实际文献需通过学术数据库验证)：
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1. **文献名称**：*TBRG1 regulates cell proliferation and apoptosis in glioblastoma via TGF-β signaling*
**作者**：Zhang Y, et al.
**摘要**：本研究通过Western blot和免疫组化技术，利用TBRG1特异性抗体分析其在胶质母细胞瘤中的表达。结果发现TBRG1通过调控TGF-β通路影响肿瘤细胞增殖和凋亡，提示其作为潜在治疗靶点。
2. **文献名称**：*The role of TBRG1 in osteoblast differentiation and bone development*
**作者**：Li H, et al.
**摘要**：研究使用TBRG1抗体进行免疫荧光染色，发现TBRG1在成骨细胞分化中高表达，并通过调控Runx2活性参与骨形成，为骨质疏松机制研究提供新方向。
3. **文献名称**：*TBRG1 as a prognostic biomarker in breast cancer: Insights from antibody-based profiling*
**作者**：Wang X, et al.
**摘要**：通过组织芯片和TBRG1抗体检测乳腺癌样本，发现TBRG1低表达与患者不良预后显著相关，提示其可能作为乳腺癌分层的生物标志物。
4. **文献名称**：*Functional characterization of TBRG1 in DNA damage response using CRISPR and antibody validation*
**作者**：Chen R, et al.
**摘要**：结合CRISPR基因编辑和TBRG1抗体验证，证实TBRG1通过ATM/ATR通路参与DNA损伤修复，敲除后显著增加细胞对辐射的敏感性。
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**提示**：以上文献名称及摘要内容为示例性质，具体文献需通过PubMed、Google Scholar等平台以关键词“TBRG1 antibody”或“TBRG1 protein”检索获取。实际研究中建议结合实验目的(如疾病模型、分子机制)进一步筛选。
**Background of TBRG1 Antibody**
The Transforming Growth Factor Beta Regulator 1 (TBRG1), also known as FAAP21. is a protein encoded by the *TBRG1* gene, implicated in cellular processes such as cell cycle regulation, DNA damage response, and transcriptional control. It interacts with key signaling pathways, including TGF-β and p53. and is involved in maintaining genomic stability. TBRG1 contains conserved domains, such as an N-terminal FHA domain and a C-terminal TBRG1-specific motif, which mediate protein-protein interactions and post-translational modifications like phosphorylation.
TBRG1 antibodies are immunological tools developed to detect and study the expression, localization, and function of the TBRG1 protein in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to investigate TBRG1's role in cancer, developmental biology, and cellular stress responses. In cancer research, TBRG1 is studied for its dual roles as a potential tumor suppressor or oncogene, depending on the cellular context, with altered expression linked to tumor progression and patient prognosis.
Commercial TBRG1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., amino acid residues 150-250). Their specificity is often validated using knockout cell lines or siRNA-mediated knockdown. Researchers rely on these antibodies to explore TBRG1's molecular interactions and regulatory mechanisms, contributing to advancements in understanding diseases like glioblastoma, breast cancer, and metabolic disorders.
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