| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MBP2; MBPH |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRG3抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*PRG3 promotes peritoneal metastasis of gastric cancer through activation of the RhoA/ROCK signaling pathway*
**作者**：Li Y, Zhang H, et al.
**摘要**：该研究揭示了PRG3在胃癌腹膜转移中的机制，发现PRG3通过激活RhoA/ROCK通路促进肿瘤细胞侵袭。研究中利用抗PRG3抗体阻断其功能，显著抑制了癌细胞迁移，提示PRG3抗体可能作为潜在治疗靶点。
2. **文献名称**：*Monoclonal antibody targeting PRG3 suppresses tumor growth in colorectal cancer models*
**作者**：Wang X, Chen J, et al.
**摘要**：团队开发了一种针对PRG3的单克隆抗体，并在结直肠癌模型中验证其疗效。实验显示，该抗体能特异性结合PRG3蛋白，抑制肿瘤细胞增殖并诱导凋亡，为PRG3抗体的临床转化提供了实验依据。
3. **文献名称**：*PRG3 as a novel biomarker for glioblastoma: Diagnostic implications of a polyclonal antibody-based assay*
**作者**：Kim S, Park D, et al.
**摘要**：本研究构建了PRG3多克隆抗体，并开发了胶质母细胞瘤的免疫组化检测方法。结果显示PRG3在肿瘤组织中高表达，与患者预后不良相关，证实该抗体在病理诊断中的应用潜力。
(注：上述文献信息为示例性质，实际引用需以具体论文内容为准。)
PRG3 (Proteoglycan 3), also known as BMPC (bone marrow proteoglycan) or bamacan, is a core component of the extracellular matrix (ECM) belonging to the small leucine-rich proteoglycan (SLRP) family. It plays a regulatory role in cell-matrix interactions, tissue organization, and cellular signaling pathways. Structurally, PRG3 consists of a core protein with leucine-rich repeats and glycosaminoglycan (GAG) chains, enabling interactions with collagen, growth factors, and cell surface receptors. Dysregulation of PRG3 has been implicated in pathological conditions, including fibrosis, inflammation, and cancer. For instance, PRG3 overexpression is observed in glioblastoma, breast cancer, and other solid tumors, where it may promote tumor progression by enhancing ECM remodeling, cell proliferation, and metastasis.
PRG3 antibodies are immunological tools designed to detect and quantify PRG3 expression in research and diagnostic contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study PRG3's spatial distribution, expression levels, and interactions in tissues or cell cultures. Recent studies also explore PRG3 as a potential biomarker for cancer prognosis or a therapeutic target. However, the functional complexity of PRG3 in ECM dynamics and disease mechanisms remains under investigation, necessitating further research to clarify its roles in health and pathology.
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