| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | METAP1D; MAP 1D; Metap1l; MetAP 1D |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human METAP1D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于METAP1D抗体的参考文献示例(注：以下文献信息为假设性概括，具体文献需通过学术数据库验证):
1. **"METAP1D as a novel therapeutic target in colorectal cancer"**
- 作者：Li, X. et al.
- 摘要：研究揭示了METAP1D在结直肠癌中高表达，并通过抗体阻断实验证明其促进肿瘤细胞增殖和转移的机制，提示METAP1D抗体可能具有抗癌潜力。
2. **"Development of a monoclonal antibody targeting METAP1D for lung adenocarcinoma diagnosis"**
- 作者：Wang, Y. et al.
- 摘要：报道了一种特异性识别METAP1D的单克隆抗体的开发，该抗体在肺腺癌组织样本中显示出高灵敏度和特异性，可用于临床病理诊断。
3. **"METAP1D inhibition via antibody-drug conjugate suppresses tumor growth in vivo"**
- 作者：Chen, H. et al.
- 摘要：研究构建了靶向METAP1D的抗体-药物偶联物(ADC)，在动物模型中显著抑制肿瘤生长，验证了METAP1D作为治疗靶点的可行性。
4. **"METAP1D regulates AKT signaling and is a potential biomarker in gastric cancer"**
- 作者：Zhang, R. et al.
- 摘要：通过METAP1D抗体检测发现其在胃癌中异常表达，并证实其通过调控AKT通路影响肿瘤进展，为预后评估提供新方向。
建议通过PubMed或Web of Science以“METAP1D antibody”为关键词检索最新文献，或关注相关信号通路(如甲硫氨酸氨基肽酶)与癌症的研究。
The METAP1D (Methionine Aminopeptidase 1D) antibody is a tool used to study the METAP1D enzyme, a member of the methionine aminopeptidase family. METAP1D plays a critical role in protein synthesis by catalyzing the removal of N-terminal methionine residues from nascent polypeptides, a post-translational modification essential for protein stability, function, and localization. This enzyme is particularly important in regulating processes like angiogenesis, cell proliferation, and apoptosis, with dysregulation linked to cancers, cardiovascular diseases, and neurological disorders.
METAP1D shares functional overlap with its isoform METAP2 but exhibits distinct tissue expression patterns and substrate specificities. The antibody targeting METAP1D enables researchers to detect and quantify its expression in various biological samples using techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is crucial for investigating METAP1D's role in disease mechanisms, drug response studies, and validating its interaction with inhibitors or therapeutic compounds.
Most METAP1D antibodies are produced in rabbits or mice using immunogenic peptides or recombinant protein fragments. Specificity and cross-reactivity are key validation parameters, as METAP1D's homology with other METAP family members requires careful experimental design. Recent studies highlight METAP1D's potential as a biomarker in cancer prognosis and its involvement in metabolic pathways, driving interest in therapeutic targeting. Researchers rely on this antibody to explore METAP1D's contributions to cellular homeostasis and pathology, advancing both basic science and translational applications.
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