| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FMO5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FMO5抗体的参考文献摘要(基于公开研究数据模拟，非真实文献)：
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1. **文献名称**: "Characterization of Flavin-Containing Monooxygenase 5 (FMO5) Antibody Specificity in Human Tissue Samples"
**作者**: Smith J, et al.
**摘要**: 本研究验证了一种高特异性FMO5抗体的应用，通过免疫组化及Western blot分析，证实FMO5蛋白在人类肝脏和肠道中高表达，并参与药物代谢与脂质氧化途径的调控。
2. **文献名称**: "Role of FMO5 in Aging-Related Metabolic Dysfunction: Insights from Knockout Mouse Models"
**作者**: Chen L, et al.
**摘要**: 利用FMO5特异性抗体检测基因敲除小鼠模型，发现FMO5缺失导致脂肪酸代谢异常，提示FMO5可能通过调控PPARα通路影响衰老相关的代谢紊乱。
3. **文献名称**: "Development of a Novel Polyclonal FMO5 Antibody for Detecting Isoform-Specific Expression in Cancer Cells"
**作者**: García-Ruiz C, et al.
**摘要**: 报道一种新型多克隆FMO5抗体的开发，验证其在结直肠癌细胞系中的特异性，发现FMO5表达与肿瘤细胞氧化应激耐受性相关，可能成为癌症治疗的潜在靶点。
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注：以上文献信息为示例性质，具体研究请参考真实数据库(如PubMed)检索。如需实际文献，建议使用关键词"FMO5 antibody"+"specificity/application"在学术平台查询。
The flavin-containing monooxygenase 5 (FMO5) is a member of the FMO enzyme family, which plays a role in the oxidative metabolism of drugs, xenobiotics, and endogenous compounds. FMOs are NADPH-dependent enzymes that oxygenate nucleophilic heteroatoms (e.g., nitrogen, sulfur) in substrates. FMO5. encoded by the *FMO5* gene in humans, is primarily expressed in the liver and kidneys. Unlike other FMO isoforms (e.g., FMO1. FMO3), FMO5 exhibits distinct substrate specificity, preferring to metabolize compounds with sulfur-containing moieties or long-chain aliphatic amines. Its precise physiological role remains less understood compared to FMO3. which is critical in trimethylamine metabolism.
FMO5 antibodies are immunological tools used to detect and quantify FMO5 protein expression in research settings. These antibodies aid in studying FMO5's tissue distribution, regulatory mechanisms, and potential involvement in disease. For instance, altered FMO5 expression has been observed in certain cancers and metabolic disorders, though its clinical significance is still under investigation. Commercially available FMO5 antibodies are typically validated for applications like Western blotting, immunohistochemistry, or ELISA. Challenges in antibody development include ensuring specificity due to structural similarities among FMO isoforms. Recent studies also explore FMO5's role in aging and lipid metabolism, linking it to pathways like PPAR signaling. Overall, FMO5 antibodies remain essential for elucidating the enzyme's biological functions and therapeutic potential.
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