| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AF1Q |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MLLT11抗体的参考文献(内容为虚构模拟，供参考)：
1. **文献名称**: *MLLT11 regulates leukemogenesis through histone modification interactions*
**作者**: Zhang L, et al.
**摘要**: 研究使用MLLT11抗体通过ChIP-seq技术揭示其在急性髓系白血病中调控组蛋白H3K79甲基化，并促进致癌基因表达的作用机制。
2. **文献名称**: *MLLT11 antibody validation for immunohistochemical profiling in solid tumors*
**作者**: Kim S, et al.
**摘要**: 本文验证了MLLT11抗体在结直肠癌组织中的特异性，发现其高表达与患者预后不良相关，提示其作为生物标志物的潜力。
3. **文献名称**: *Functional characterization of MLLT11 in transcriptional elongation using CRISPR and antibody-based assays*
**作者**: Patel R, et al.
**摘要**: 结合CRISPR基因编辑和MLLT11抗体Western blot分析，证明MLLT11通过与RNA聚合酶II相互作用调控基因转录延伸过程。
(注：以上文献为虚构示例，实际研究需通过PubMed/Google Scholar等平台检索关键词"MLLT11 antibody"或"ENSG00000116285"获取。)
The MLLT11 antibody is designed to target the MLLT11 protein, also known as ELL-associated factor 2 (EAF2), a component of the super elongation complex (SEC) that regulates transcriptional elongation by RNA polymerase II. MLLT11 plays a critical role in hematopoiesis and has been implicated in chromosomal translocations, particularly with the MLL (Mixed-Lineage Leukemia) gene in acute leukemias. These translocations generate oncogenic fusion proteins that disrupt normal transcriptional regulation, contributing to leukemogenesis.
MLLT11 is involved in modulating chromatin structure, histone acetylation, and transcriptional activation, often interacting with other elongation factors like ELL and P-TEFb. Its dysregulation is associated with aggressive cancer phenotypes, including cell proliferation and apoptosis resistance. Antibodies against MLLT11 are widely used in research to study its expression patterns, subcellular localization, and interactions in both normal and malignant cells. They are essential tools in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), aiding in the exploration of its role in transcriptional control and disease mechanisms.
Research using MLLT11 antibodies has provided insights into its dual roles as a tumor suppressor in certain contexts and an oncogenic collaborator in others, highlighting its therapeutic potential in targeting SEC-dependent cancers. These studies underscore its relevance in understanding hematologic malignancies and developing targeted therapies.
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