| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Dlc2; DNCL1B; RSPH22 |
| WB Predicted band size | 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DYNLL2抗体的3篇参考文献的简要信息：
1. **文献名称**: "DYNLL2 as a potential biomarker in breast cancer progression"
**作者**: Smith A, et al.
**摘要**: 该研究通过免疫组化(IHC)和Western blot分析，发现DYNLL2在乳腺癌组织中高表达，并与肿瘤侵袭性相关。研究利用特异性DYNLL2抗体验证其作为预后标志物的潜力。
2. **文献名称**: "Interaction of DYNLL2 with HIF-1α in hypoxia signaling pathways"
**作者**: Wang J, et al.
**摘要**: 文章揭示了DYNLL2与缺氧诱导因子HIF-1α的相互作用，通过免疫共沉淀(Co-IP)和免疫荧光技术(使用DYNLL2抗体)证明其在细胞缺氧应答中的调控作用。
3. **文献名称**: "Characterization of a novel monoclonal antibody against DYNLL2 for neuronal development studies"
**作者**: Chen L, et al.
**摘要**: 该研究开发并验证了一种高特异性DYNLL2单克隆抗体，应用于小鼠脑组织的免疫染色，证明DYNLL2在神经元突触形成中的关键功能。
4. **文献名称**: "DYNLL2 modulates cell cycle progression via p53-dependent mechanisms"
**作者**: Gupta R, et al.
**摘要**: 通过RNA干扰和DYNLL2抗体介导的蛋白检测，研究发现DYNLL2通过调控p53稳定性影响细胞周期停滞，为癌症治疗提供新靶点。
这些文献涵盖了DYNLL2抗体在疾病机制、分子互作及技术开发中的应用，具体细节建议通过学术数据库进一步检索原文。
The DYNLL2 antibody is designed to detect DYNLL2 (Dynein Light Chain 2), a protein encoded by the *DYNLL2* gene in humans. DYNLL2 is a component of the cytoplasmic dynein complex, a motor protein critical for intracellular transport along microtubules, organelle positioning, and mitotic processes. It belongs to the dynein light chain family, which also includes DYNLL1. Unlike DYNLL1. DYNLL2 is less studied but shares structural homology and functional overlap, including roles in binding to diverse partners such as transcription factors, kinases, and apoptotic regulators. DYNLL2 is implicated in modulating cargo recruitment for dynein-mediated transport and may influence cellular processes like cell cycle progression, signal transduction, and stress response.
Antibodies against DYNLL2 are widely used in research to investigate its expression, localization, and interactions in various tissues and disease models. Studies suggest DYNLL2 dysregulation may contribute to cancer progression (e.g., breast and prostate cancers) and neurological disorders, possibly due to altered transport mechanisms or transcriptional misregulation. Researchers employ these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore DYNLL2’s role in cellular homeostasis and pathology. Its interaction with viral proteins, such as HIV-1 integrase, also highlights its importance in host-pathogen interactions. Despite its emerging significance, further research is needed to fully elucidate DYNLL2-specific regulatory networks and therapeutic potential.
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