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Rabbit Polyclonal XKR6 Antibody

  • 中文名: XKR6抗体
  • 别    名: XRG6; C8orf5; C8orf7; C8orf21
货号: IPDX02037
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/150-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesXRG6; C8orf5; C8orf7; C8orf21
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human XKR6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下为模拟生成的3篇与XKR6抗体相关的参考文献示例,供参考。实际文献请通过学术数据库(如PubMed、Google Scholar)检索确认:

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1. **文献名称**: "XKR6 regulates apoptotic cell clearance by mediating phosphatidylserine exposure"

**作者**: Suzuki Y, et al.

**摘要**: 本研究揭示了XKR6蛋白在凋亡细胞表面磷脂酰丝氨酸(PS)外翻中的关键作用,并开发了一种特异性识别XKR6的小鼠单克隆抗体。通过免疫印迹和免疫荧光实验验证了该抗体在检测HeLa细胞和巨噬细胞中XKR6表达的可靠性,为研究细胞凋亡机制提供了工具。

2. **文献名称**: "Structural characterization of XKR6 using cryo-EM and antibody-based epitope mapping"

**作者**: Tanaka R, et al.

**摘要**: 通过冷冻电镜解析了XKR6的跨膜结构域,并利用兔多克隆抗体定位其胞外抗原表位。研究发现XKR6抗体可特异性结合其C端结构域,阻断其与Xk家族其他成员的相互作用,提示其在神经退行性疾病中的潜在治疗价值。

3. **文献名称**: "XKR6 antibody as a biomarker for early-stage colorectal cancer detection"

**作者**: Wang L, et al.

**摘要**: 通过ELISA和免疫组化分析,发现XKR6在结直肠癌患者血清和组织中显著高表达。研究团队开发的抗人XKR6 IgG抗体在早期癌症诊断中显示出高灵敏度和特异性,为临床筛查提供了新策略。

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**提示**:

- 以上内容为模拟生成,实际文献需结合具体研究目标检索。

- 若需真实文献,建议检索关键词 "XKR6 antibody" 或 "XKR6 function",并筛选涉及抗体开发、验证或应用的论文。

背景信息

The XKR6 antibody is a research tool designed to target the XKR6 protein, a member of the XK-related family implicated in cellular processes such as apoptosis and phospholipid scrambling. The XKR family, including XKR6. shares structural homology with the XK protein, which is linked to neurodegenerative disorders like McLeod syndrome. While XKR6’s precise biological role remains under investigation, studies suggest its involvement in phosphatidylserine externalization—a hallmark of apoptotic cells—and potential regulation of cell death signaling pathways. This antibody enables detection and analysis of XKR6 expression in various experimental models, aiding research into its function in physiological and pathological contexts, such as cancer or immune regulation. Despite progress, the mechanistic details of XKR6 activity, including its interaction partners and tissue-specific roles, require further elucidation. Current applications of the XKR6 antibody include Western blotting, immunohistochemistry, and flow cytometry, supporting both basic research and translational studies exploring its utility as a biomarker or therapeutic target. Ongoing efforts aim to clarify its contribution to cellular homeostasis and disease, positioning XKR6 as a protein of growing interest in cell biology and biomedicine.

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