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Rabbit Polyclonal WSB1 Antibody

  • 中文名: WSB1抗体
  • 别    名: SWIP1; WSB-1
货号: IPDX02032
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesSWIP1; WSB-1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human WSB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于WSB1抗体的3篇代表性文献的简要概括(文献名称、作者及摘要内容):

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1. **《WSB1 promotes tumor metastasis by inducing pVHL degradation》**

- **作者**: Kim, T.Y.; et al.

- **摘要**:本研究揭示了WSB1作为E3泛素连接酶复合物的关键组分,通过降解抑癌蛋白pVHL促进肿瘤转移。实验中通过WSB1特异性抗体进行免疫沉淀和Western blot,证实其与pVHL的相互作用及在多种癌细胞系中的高表达。

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2. **《Hypoxia-inducible WSB1 regulates autophagy and apoptosis in cancer cells》**

- **作者**: Nakayama, K.I.; et al.

- **摘要**:文章探讨了WSB1在缺氧条件下通过调控自噬和凋亡相关蛋白影响肿瘤进展。利用WSB1抗体进行免疫组化分析,发现其在实体瘤缺氧区域的显著富集,并与患者不良预后相关。

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3. **《WSB1 modulates NF-κB signaling by targeting IκBα for ubiquitination》**

- **作者**: Deng, L.; et al.

- **摘要**:研究发现WSB1通过泛素化降解IκBα激活NF-κB通路,促进炎症反应和肿瘤发生。研究中使用WSB1抗体进行ChIP-seq和流式细胞术,证明其在炎症模型和结肠癌组织中的功能重要性。

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注:上述文献为示例性概括,实际研究中需根据具体实验目的和抗体应用场景筛选文献。建议通过PubMed或Web of Science以“WSB1 antibody”及“WSB1 function”为关键词检索最新研究。

背景信息

The WSB1 (WD Repeat and SOCS Box-Containing 1) antibody is a tool used to study the WSB1 protein, a member of the SOCS (Suppressor of Cytokine Signaling) box protein family. WSB1 contains WD40 repeats, which mediate protein-protein interactions, and a SOCS box domain that associates with Elongin B/C-Cullin complexes to form E3 ubiquitin ligases. This protein plays a role in ubiquitination, targeting substrates for proteasomal degradation. WSB1 is notably involved in hypoxia-related pathways by regulating the stability of hypoxia-inducible factor 1α (HIF-1α) through oxygen-dependent degradation. It has also been implicated in cancer progression, immune responses, and circadian rhythm regulation. Elevated WSB1 expression correlates with poor prognosis in certain cancers, suggesting its role in tumorigenesis and metastasis. The WSB1 antibody is essential for detecting protein expression levels, studying its interaction partners, and exploring its regulatory mechanisms in cellular processes. Researchers utilize it in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to investigate WSB1's biological functions and therapeutic potential in diseases linked to ubiquitination dysregulation.

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