| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HBZ1; HBZ-T1 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HBZ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VPS41抗体的参考文献示例(文献信息为虚构示例，仅供参考格式)：
1. **文献名称**：VPS41 regulates lysosomal membrane trafficking in neuronal cells
**作者**：Smith A, et al.
**摘要**：本研究利用VPS41抗体通过免疫荧光和Western blot验证了VPS41蛋白在神经元中的定位及表达水平，发现其参与溶酶体膜融合过程，与神经退行性疾病相关通路有关。
2. **文献名称**：Functional characterization of VPS41 in autophagy using specific antibodies
**作者**：Chen L, et al.
**摘要**：通过VPS41抗体的免疫共沉淀实验，揭示了VPS41与自噬相关蛋白HOPS复合体的相互作用，证明其在自噬体-溶酶体融合中的关键作用。
3. **文献名称**：VPS41 antibody-based screening identifies mutations linked to Parkinson's disease
**作者**：Wang X, et al.
**摘要**：研究采用VPS41抗体对患者样本进行蛋白质印迹分析，发现VPS41表达异常与帕金森病中溶酶体功能障碍存在显著相关性。
4. **文献名称**：Role of VPS41 in endosomal sorting revealed by antibody-mediated inhibition
**作者**：Gomez R, et al.
**摘要**：通过VPS41抗体的功能阻断实验，证实了VPS41在内体分选途径中的必要性，并阐明了其调控膜运输的分子机制。
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**注**：以上文献为示例，实际引用请通过PubMed或Google Scholar检索关键词"VPS41 antibody"获取真实文献。
VPS41 (Vacuolar Protein Sorting 41) is a critical component of the HOPS (Homotypic Fusion and Vacuole Protein Sorting) complex, which regulates membrane trafficking and fusion events in eukaryotic cells. It plays a key role in lysosome-related organelle biogenesis, endosomal-lysosomal transport, and autophagy by facilitating vesicle docking and fusion. Dysregulation of VPS41 is linked to neurodegenerative disorders like Parkinson’s and Alzheimer’s disease, as well as Hermansky-Pudlak syndrome, a genetic condition affecting lysosome function and pigmentation.
VPS41 antibodies are essential tools for studying these processes. They enable detection and localization of VPS41 in cells or tissues via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Researchers use these antibodies to investigate VPS41 expression levels, interactions with HOPS complex partners (e.g., VPS39. VPS18), and its role in pathological conditions. Polyclonal or monoclonal variants are typically raised in hosts like rabbits or mice, often validated for specificity using knockout controls.
Studies employing VPS41 antibodies have clarified its involvement in neuronal survival, melanosome maturation, and cellular responses to stress. Such insights highlight its potential as a therapeutic target for diseases linked to lysosomal dysfunction or impaired protein trafficking.
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