| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | 65K; SAD1; CGI-21; HSPC332; SNRNP65 |
| WB Predicted band size | 65 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human USP39 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及USP39抗体的文献摘要信息(基于公开研究整理，非真实文献，仅作示例参考)：
1. **文献名称**：USP39 regulates cell cycle progression through the stabilization of CDK1 in hepatocellular carcinoma
**作者**：Li X, et al.
**摘要**：该研究利用USP39抗体进行免疫印迹和免疫组化实验，发现USP39通过去泛素化作用稳定CDK1蛋白，促进肝癌细胞G2/M期转换和增殖。
2. **文献名称**：USP39 interacts with the spliceosome and modulates pre-mRNA splicing in human cells
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀(Co-IP)结合USP39抗体，揭示了USP39与剪接体复合物的相互作用，调控特定mRNA剪接事件，影响细胞应激反应。
3. **文献名称**：Targeting USP39 enhances sensitivity to DNA-damaging agents in breast cancer
**作者**：Chen L, et al.
**摘要**：研究使用USP39抗体进行免疫荧光染色，证实抑制USP39可降低BRCA1蛋白稳定性，增强乳腺癌细胞对化疗药物顺铂的敏感性。
(注：以上文献为模拟示例，实际文献需通过PubMed或Google Scholar等数据库检索关键词“USP39 antibody”或“USP39 function”获取。)
The ubiquitin-specific protease 39 (USP39) is a deubiquitinating enzyme involved in pre-mRNA splicing and cell cycle regulation. As a component of the spliceosome, USP39 plays a critical role in spliceosome assembly and catalytic activation, contributing to mRNA maturation and genomic stability. Studies have linked USP39 to the regulation of key cell cycle checkpoints, particularly through interactions with proteins like Aurora B and cyclin-dependent kinases. Dysregulation of USP39 has been implicated in various cancers, including hepatocellular carcinoma, breast cancer, and colorectal cancer, where its overexpression often correlates with tumor progression, metastasis, and poor prognosis.
USP39 antibodies are essential tools for investigating its biological functions and clinical relevance. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect USP39 expression levels, subcellular localization, and protein-protein interactions. Specificity and validation are crucial, as USP39 shares structural homology with other spliceosomal components. Researchers utilize these antibodies to explore USP39's role in splicing defects, DNA damage response, and therapeutic resistance. Commercially available USP39 antibodies are typically raised against epitopes in its conserved N-terminal or C-terminal regions. Ongoing studies aim to clarify USP39's dual roles in maintaining cellular homeostasis and promoting oncogenesis, highlighting its potential as a diagnostic marker or therapeutic target in precision oncology.
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