| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | UDPG; UGP1; UDPGP; UGPP1; UGPP2; UDPGP2; pHC379 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human UGP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UGP2抗体的3篇虚构参考文献示例，格式包括文献名称、作者及摘要概括：
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1. **文献名称**: *UGP2 Antibody Characterization in Glycogen Synthesis Studies*
**作者**: Zhang L, et al.
**摘要**: 本研究利用新型UGP2特异性抗体，通过免疫印迹和免疫荧光技术，揭示了UGP2在肝细胞糖原合成中的关键作用。实验表明UGP2表达水平与2型糖尿病模型中的糖原代谢异常显著相关，抗体特异性验证为后续代谢疾病研究提供了可靠工具。
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2. **文献名称**: *UGP2 as a Biomarker in Glioblastoma: Insights from Immunohistochemical Analysis*
**作者**: Smith JR, et al.
**摘要**: 通过抗UGP2抗体进行组织染色，研究发现UGP2在胶质母细胞瘤中高表达，且与肿瘤侵袭性正相关。该抗体成功应用于患者组织样本分析，提示UGP2可能成为神经胶质瘤治疗的新靶点。
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3. **文献名称**: *Role of UGP2 in Lipid Metabolism: Evidence from Knockout Mice Models*
**作者**: Tanaka K, et al.
**摘要**: 利用UGP2抗体检测基因敲除小鼠的脂肪组织，发现UGP2缺失导致脂质合成通路紊乱。研究证实UGP2通过调控UDP-葡萄糖水平影响脂代谢平衡，为肥胖相关机制提供了新视角。
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注：以上文献为模拟示例，实际研究中建议通过PubMed或Web of Science检索真实文献。
**Background of UGP2 Antibody**
UGP2 (UDP-glucose pyrophosphorylase 2) is a key enzyme involved in carbohydrate metabolism, catalyzing the reversible synthesis of UDP-glucose from glucose-1-phosphate and UTP. UDP-glucose serves as a critical precursor for glycogen synthesis, cell wall polysaccharides, and protein glycosylation, making UGP2 indispensable in energy storage and cellular homeostasis. While UGP1. a homologous isoform, is ubiquitously expressed, UGP2 exhibits tissue-specific expression, predominantly in the liver, muscle, and brain, suggesting distinct regulatory roles in glucose utilization and glycogen dynamics.
Antibodies targeting UGP2 are essential tools for studying its expression, localization, and function in metabolic pathways. They enable researchers to detect UGP2 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the exploration of its tissue distribution and regulatory mechanisms. Such antibodies are particularly valuable in metabolic disorder research, as dysregulation of UGP2 has been implicated in conditions like diabetes, glycogen storage diseases, and certain cancers characterized by altered glucose metabolism.
Furthermore, UGP2 antibodies contribute to elucidating the enzyme's role in stress responses and developmental processes, where UDP-glucose signaling intersects with pathways like ER stress and inflammatory signaling. By facilitating precise detection and functional analysis, UGP2 antibodies support advancements in understanding metabolic diseases and therapeutic targeting.
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