| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HCG-1; PNSC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟的关于UBL3抗体的参考文献示例，供参考：
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1. **文献名称**：*UBL3 modulates vesicular secretion through antibody-based localization studies*
**作者**：Smith A, et al. (2020)
**摘要**：本研究利用特异性UBL3抗体，通过免疫荧光和Western blot技术，揭示了UBL3蛋白在外泌体分泌中的关键作用，证实其与细胞膜运输蛋白的相互作用。
2. **文献名称**：*Development of a monoclonal antibody for UBL3 and its application in cancer prognosis*
**作者**：Zhang L, et al. (2018)
**摘要**：作者开发了一种高亲和力的UBL3单克隆抗体，并应用于组织微阵列分析，发现UBL3在多种癌症中表达下调，且低表达与患者不良预后显著相关。
3. **文献名称**：*Structural insights into UBL3-antibody complexes reveal functional domains*
**作者**：Jones R, et al. (2021)
**摘要**：通过冷冻电镜结合UBL3抗体，解析了UBL3蛋白的构象变化，阐明其C端结构域在泛素化信号通路中的调控机制。
4. **文献名称**：*UBL3 antibody-based detection in neurodegenerative disease models*
**作者**：Lee H, et al. (2019)
**摘要**：研究使用UBL3抗体检测阿尔茨海默病小鼠模型脑组织，发现UBL3与错误折叠蛋白的共定位，提示其可能参与病理蛋白清除过程。
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**说明**：以上文献为模拟示例，实际引用需以真实数据库(如PubMed、Web of Science)检索结果为准。建议通过关键词“UBL3 antibody”或结合具体研究领域进一步筛选文献。
Ubiquitin-like protein 3 (UBL3), also known as membrane-anchored ubiquitin-fold protein (MUB), is a small (~12 kDa) post-translationally modified protein belonging to the ubiquitin-like family. Unlike ubiquitin, UBL3 lacks a C-terminal diglycine motif required for canonical ubiquitination but contains a conserved C-terminal prenylation site (CAAX box) that enables its attachment to cellular membranes via farnesylation. UBL3 is implicated in membrane trafficking, protein sorting, and the regulation of cell surface receptor internalization. It interacts with ESCRT (Endosomal Sorting Complex Required for Transport) machinery and may modulate vesicular transport or viral budding processes.
Antibodies targeting UBL3 are critical tools for studying its localization, interactions, and roles in cellular processes. These antibodies are typically validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. Research suggests UBL3 participates in neurodegenerative diseases and cancer, with altered expression observed in conditions like Alzheimer’s disease and certain carcinomas. However, its precise molecular mechanisms remain under investigation. Commercially available UBL3 antibodies are often raised against conserved regions (e.g., N-terminal residues 1-50) and require validation using knockout cell lines or siRNA-mediated knockdown to confirm specificity. Understanding UBL3's function through antibody-based assays may shed light on its involvement in membrane dynamics and disease pathways.
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