Rabbit Polyclonal TMPRSS11D Antibody

The TMPRSS11D antibody targets TMPRSS11D, a member of the type II transmembrane serine protease (TTSP) family, which plays roles in proteolytic cleavage, cellular signaling, and tissue homeostasis. TMPRSS11D, also known as human airway trypsin-like protease (HAT), is predominantly expressed in epithelial tissues, particularly the respiratory tract. It is implicated in modulating host-pathogen interactions, including viral entry mechanisms for influenza A and coronaviruses by cleaving viral surface glycoproteins. Research on TMPRSS11D antibodies focuses on detecting protein expression, localization, and functional studies to explore its physiological and pathological roles. These antibodies are critical tools for investigating TMPRSS11D's involvement in respiratory diseases, cancer progression (e.g., lung and prostate cancers), and its potential as a therapeutic target. Recent studies also highlight its dual role in both promoting viral infectivity and contributing to innate immune responses. Commercially available TMPRSS11D antibodies are used in techniques like Western blotting, immunohistochemistry, and ELISA. However, challenges remain in specificity and cross-reactivity due to homology within the TTSP family. Understanding TMPRSS11D's molecular mechanisms through antibody-based research may advance diagnostics and treatments for infectious and inflammatory diseases.