| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CC3; TIP30; SDR44U1 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HTATIP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HTATIP2抗体的3篇参考文献示例(注：文献为示例性内容，实际文献需根据具体数据库检索确认)：
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1. **文献名称**: *"TIP30 regulates apoptosis, angiogenesis, and metastasis in human tumor cells"*
**作者**: Shtivelman E, et al.
**摘要**: 该研究揭示了HTATIP2(TIP30)在调控肿瘤细胞凋亡、血管生成和转移中的作用。作者利用特异性抗体检测了TIP30在多种癌细胞系中的表达，发现其缺失与肿瘤侵袭性增强相关，提示其作为抑癌基因的功能。
2. **文献名称**: *"Development of a monoclonal antibody against HTATIP2 for immunohistochemical analysis in breast cancer"*
**作者**: Zhang L, et al.
**摘要**: 研究团队开发了一种针对HTATIP2的单克隆抗体，并通过免疫组化验证其在乳腺癌组织中的特异性。结果显示HTATIP2低表达与患者预后不良显著相关，支持其作为乳腺癌生物标志物的潜力。
3. **文献名称**: *"The role of TIP30 in oxidative stress-induced neuronal apoptosis"*
**作者**: Wang Y, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，使用HTATIP2抗体探讨了TIP30在神经元氧化应激反应中的作用。结果表明，TIP30通过调控线粒体途径促进凋亡，为神经退行性疾病机制提供了新见解。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“HTATIP2 antibody”或“TIP30 antibody”，并筛选涉及抗体开发、验证或应用的实验性研究。
The HTATIP2 antibody targets HTATIP2 (HIV-1 Tat-interacting protein 2), also known as TIP60 or KAT5. a histone acetyltransferase belonging to the MYST family. This protein plays a critical role in chromatin remodeling, DNA repair, and transcriptional regulation by acetylating histones and non-histone substrates. TIP60 is involved in cellular processes such as apoptosis, cell cycle control, and response to DNA damage, making it essential for maintaining genomic stability. Dysregulation of TIP60 has been linked to cancer progression, neurodegenerative diseases, and viral infection mechanisms, particularly HIV-1 replication through its interaction with the viral Tat protein.
Antibodies against HTATIP2 are widely used in research to study its expression, localization, and functional interactions. They enable techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore TIP60's role in signaling pathways and disease contexts. For example, reduced TIP60 levels have been observed in certain cancers, correlating with poor prognosis, while its activation is implicated in suppressing tumor growth under specific conditions. Researchers also utilize HTATIP2 antibodies to investigate epigenetic modifications and therapeutic targets, given TIP60's dual role as an oncogene or tumor suppressor depending on cellular context. Validating antibody specificity is crucial, as cross-reactivity with other acetyltransferases may affect data interpretation.
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