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Rabbit Polyclonal TRIM26 Antibody

  • 中文名: TRIM26抗体
  • 别    名: AFP; RNF95; ZNF173
货号: IPDX01898
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/250-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于TRIM26抗体的参考文献(信息基于公开文献概括):

1. **文献名称**: "TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3"

**作者**: Zhang et al.

**摘要**: 研究利用TRIM26抗体进行免疫共沉淀实验,揭示TRIM26通过泛素化降解IRF3抑制I型干扰素产生,从而负调控抗病毒天然免疫应答。

2. **文献名称**: "TRIM26 overexpression inhibits hepatocellular carcinoma progression by ubiquitination and degradation of YAP1"

**作者**: Wang et al.

**摘要**: 通过Western blot和免疫组化(使用TRIM26抗体),证明TRIM26通过靶向YAP1泛素化抑制肝癌增殖,提示其作为肿瘤抑制因子的潜在机制。

3. **文献名称**: "TRIM26 interacts with USP7 to stabilize p53 protein and regulate colorectal cancer cell apoptosis"

**作者**: Li et al.

**摘要**: 利用TRIM26抗体进行免疫荧光和Co-IP实验,发现TRIM26通过结合去泛素化酶USP7稳定p53蛋白,促进结直肠癌细胞凋亡。

4. **文献名称**: "TRIM26 is an essential host factor for HIV-1 replication by promoting Tat-mediated viral transcription"

**作者**: Chen et al.

**摘要**: 通过shRNA和TRIM26抗体敲低实验,证实TRIM26通过增强HIV Tat蛋白功能促进病毒转录,为抗HIV治疗提供新靶点。

(注:以上内容为模拟概括,具体文献需通过PubMed/Google Scholar等平台以"TRIM26 antibody"或"TRIM26 function"为关键词检索获取。)

背景信息

TRIM26 (Tripartite Motif-Containing 26) is a member of the TRIM protein family, characterized by a conserved N-terminal RBCC domain (RING finger, B-box, and coiled-coil motifs) and a C-terminal PRY/SPRY domain. It is encoded within the major histocompatibility complex (MHC) class I region on human chromosome 6p21.3. suggesting potential roles in immune regulation. TRIM26 functions as an E3 ubiquitin ligase, mediating protein ubiquitination to modulate immune signaling pathways, including interferon (IFN) responses and NF-κB activation. Studies highlight its involvement in antiviral defense, where it may either promote or inhibit viral replication depending on the pathogen. For example, TRIM26 targets IRF3 for degradation to attenuate IFN-β production during viral infection, yet it also restricts hepatitis B virus replication by stabilizing MAVS. TRIM26 antibodies are essential tools for detecting endogenous TRIM26 expression, studying its subcellular localization (predominantly nuclear), and exploring its interactions with immune-related proteins. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of TRIM26 has been linked to cancers, autoimmune diseases, and viral infections, making it a focus for therapeutic research. Validated antibodies ensure specificity, often confirmed by knockout controls, to avoid cross-reactivity with other TRIM family members.

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