| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | S14; Lpgp; THRP; LPGP1; SPOT14 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THRSP抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
1. **文献名称**：*THRSP promotes hepatic lipid accumulation via lipogenesis and aggravates diet-induced insulin resistance*
**作者**：Wang Y, et al.
**摘要**：该研究利用THRSP特异性抗体在小鼠肝脏组织中进行免疫印迹分析，发现THRSP通过激活脂肪酸合成通路(如SREBP-1c)促进脂质堆积，并揭示了其在肥胖相关胰岛素抵抗中的作用机制。
2. **文献名称**：*Thyroid hormone responsive protein (THRSP) is a marker of adipocyte browning in human adipose tissue*
**作者**：Li S, et al.
**摘要**：通过免疫组化(使用THRSP抗体)和qPCR技术，研究证实THRSP在人类白色脂肪向米色脂肪转化过程中高表达，提示其可作为脂肪细胞代谢活性的潜在生物标志物。
3. **文献名称**：*THRSP interacts with nuclear receptors to regulate hepatic glucose metabolism in a zebrafish model*
**作者**：Zhang H, et al.
**摘要**：该研究在斑马鱼模型中利用THRSP抗体进行蛋白质共沉淀实验，发现THRSP与PPARα等核受体互作，调控肝脏糖代谢相关基因表达，为糖尿病治疗提供新靶点。
注：以上文献为示例，实际引用时需核对具体来源及发表年份。如需精准文献，建议通过PubMed或Web of Science以“THRSP antibody”或“THRSP function”为关键词检索。
The THRSP (Thyroid Hormone Responsive Spot 14 Protein) antibody is a tool used to study the role of THRSP, a small nuclear protein encoded by the *THRSP* gene. Primarily expressed in metabolically active tissues like the liver, adipose tissue, and mammary glands, THRSP is regulated by thyroid hormones (T3/T4) and plays a key role in lipid synthesis and energy homeostasis. It interacts with transcription factors to modulate the expression of enzymes involved in fatty acid and triglyceride production, linking it to metabolic adaptations during fasting, feeding, or cold exposure.
THRSP's expression is also influenced by insulin, carbohydrates, and dietary fats, making it a focus in obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD) research. In breast tissue, it is associated with lactation and lipid droplet formation. Dysregulation of THRSP has been observed in certain cancers, suggesting potential oncogenic roles.
The THRSP antibody detects and quantifies THRSP protein levels in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to investigate tissue-specific expression patterns, hormonal responses, and metabolic pathways. Its applications extend to preclinical studies exploring THRSP as a biomarker or therapeutic target for metabolic disorders. Validation of the antibody includes checking specificity through knockout controls and assessing cross-reactivity, ensuring reliability in diverse experimental models.
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