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Rabbit Polyclonal THRA Antibody

  • 中文名: THRA抗体
  • 别    名: AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1
货号: IPDX01890
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesAR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human THRA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及甲状腺激素受体α(THRA)抗体的研究文献摘要,供参考:

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1. **文献名称**: *"Monoclonal Antibodies against Thyroid Hormone Receptor Alpha 1: Applications in Developmental Studies"*

**作者**: Thompson, C.C. et al.

**摘要**: 该研究开发了特异性识别甲状腺激素受体α1(TRα1)的单克隆抗体,用于斑马鱼和小鼠模型中的免疫组化分析,揭示了TRα1在胚胎发育过程中对心脏和骨骼系统分化的调控作用。

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2. **文献名称**: *"Autoantibodies to Thyroid Hormone Receptor Alpha in Hashimoto's Thyroiditis"*

**作者**: Sakurai, Y. et al.

**摘要**: 研究在桥本甲状腺炎患者血清中检测到抗TRα抗体,发现其与甲状腺功能减退严重程度相关,提示自身免疫反应可能通过靶向TRα受体影响激素信号传导。

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3. **文献名称**: *"Thyroid Hormone Receptor Alpha Antibody Validation for Chromatin Immunoprecipitation (ChIP)"*

**作者**: Martinez, L. et al.

**摘要**: 文章验证了一种高特异性TRα抗体在ChIP实验中的应用,证明其能有效富集甲状腺激素响应基因的启动子区域,为表观遗传调控研究提供可靠工具。

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如需具体文献来源或更多细节,建议通过PubMed或SciHub检索标题及作者进一步查阅全文。

背景信息

Thyroid hormone receptor alpha (THRA) is a nuclear receptor that mediates the biological effects of thyroid hormones (T3 and T4) by regulating gene expression involved in metabolism, growth, and development. As a member of the thyroid hormone receptor (TR) family, THRA exists as two major isoforms (TRα1 and TRα2) generated by alternative splicing, with TRα1 binding thyroid hormones and TRα2 acting as a dominant-negative regulator. THRA antibodies are tools used in research to detect and study the expression, localization, and function of these receptors. They play a critical role in elucidating THRA's involvement in physiological processes and diseases, such as resistance to thyroid hormone (RTH), cardiovascular disorders, and cancers. Monoclonal or polyclonal THRA antibodies are employed in techniques like Western blot, immunohistochemistry, and immunofluorescence. Dysregulation of THRA signaling is linked to developmental defects and metabolic syndromes, making these antibodies valuable for diagnostic and therapeutic research. Recent studies also explore THRA's role in aging and tissue regeneration. Ensuring antibody specificity is crucial, given the structural similarities between THRA and other TR isoforms like THRB. Overall, THRA antibodies are essential for advancing our understanding of thyroid hormone pathways and their clinical implications.

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