| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/35-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TAF2I; PRO2134; TAFII28; MGC:15243 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TAF11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TAF11抗体的3篇参考文献示例(文献为虚构，仅供格式参考)：
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1. **文献名称**：Structural insights into TAF11's role in TFIID complex assembly
**作者**：Trowitzsch S, et al.
**摘要**：通过X射线晶体学和免疫共沉淀技术，研究TAF11在TFIID复合体中的结构功能，使用TAF11抗体验证其与TAF6的相互作用，揭示其在RNA聚合酶II转录起始中的关键作用。
2. **文献名称**：TAF11 overexpression promotes hepatocellular carcinoma via cell cycle dysregulation
**作者**：Shen L, et al.
**摘要**：利用TAF11特异性抗体进行Western blot和免疫组化，发现TAF11在肝癌组织中高表达，并通过调控Cyclin D1加速G1/S期转化，提示其作为癌症治疗靶点的潜力。
3. **文献名称**：TAF11 interacts with viral oncoproteins to modulate HPV transcription
**作者**：Mammoto T, et al.
**摘要**：通过ChIP-seq和TAF11抗体染色，证明HPV E7蛋白与TAF11结合并改变宿主基因转录模式，揭示TAF11在病毒致癌中的调控机制。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“TAF11 antibody”或“TAF11 function”。
**Background of TAF11 Antibody**
TAF11 (TATA-box binding protein-associated factor 11) is a subunit of the transcription factor TFIID complex, which plays a critical role in RNA polymerase II-mediated transcription initiation. As part of the TFIID complex, TAF11 interacts with other TAF proteins and core promoter elements to facilitate the assembly of the pre-initiation complex, ensuring precise regulation of gene expression. TAF11 is also implicated in chromatin remodeling, cell cycle progression, and apoptosis, with studies linking its dysregulation to cancers, viral infection responses, and developmental disorders.
Antibodies targeting TAF11 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study TAF11's role in transcription mechanisms or disease contexts. For example, TAF11 antibodies have helped uncover its overexpression in certain cancers (e.g., prostate cancer) and its involvement in viral replication processes (e.g., HIV). Additionally, these antibodies aid in exploring TAF11's partnership with histone-fold domain proteins to stabilize the TFIID structure.
Research using TAF11 antibodies continues to advance understanding of transcriptional dysregulation in pathologies, offering potential insights for therapeutic targeting.
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