| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant human IgG3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于STX7(Syntaxin 7)抗体的3篇参考文献示例(内容基于典型研究场景，建议通过学术数据库核实具体文献)：
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1. **文献名称**: "Syntaxin 7 mediates endosomal trafficking to the lysosome"
**作者**: Wang et al.
**摘要**: 研究证实STX7在晚期内体-溶酶体膜融合中的作用，通过Western blot和免疫荧光实验(使用STX7特异性抗体)揭示了其与VAMP7的相互作用，并发现其缺失导致溶酶体功能异常。
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2. **文献名称**: "Role of Syntaxin 7 in autophagosome-lysosome fusion"
**作者**: Nakamura & Yoshimori
**摘要**: 利用STX7抗体进行共聚焦显微镜观察，发现STX7参与自噬体与溶酶体的融合过程，敲低STX7后自噬降解受阻，表明其在细胞自噬中的关键调控作用。
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3. **文献名称**: "Characterization of Syntaxin 7 knockout mice reveals immune cell defects"
**作者**: Smith et al.
**摘要**: 通过免疫组化(STX7抗体标记)和流式细胞术分析，发现STX7缺失小鼠的巨噬细胞内吞和抗原呈递功能受损，提示STX7在免疫系统中的重要性。
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**备注**：以上为示例文献，实际引用时需通过PubMed或Google Scholar检索真实文献(关键词：Syntaxin 7 antibody, STX7 function)。部分商业化抗体公司(如Abcam、Cell Signaling)的技术手册也可提供抗体验证数据。
The STX7 antibody is a tool used to detect Syntaxin 7. a member of the SNARE (Soluble NSF Attachment Protein Receptor) protein family involved in intracellular membrane trafficking and fusion. Syntaxin 7 localizes primarily to late endosomes and lysosomes, where it facilitates vesicle docking and cargo transport, particularly in endocytic and autophagic pathways. Research on STX7 has highlighted its role in organelle maturation, phagosome-lysosome fusion, and autophagy, processes critical for cellular homeostasis and immune responses.
Antibodies targeting STX7 are widely employed in studies investigating membrane dynamics, vesicle trafficking, and lysosomal function. They enable detection of Syntaxin 7 expression levels, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These applications are pivotal in understanding pathologies linked to trafficking defects, such as neurodegenerative diseases, cancer, and immune disorders.
STX7 antibodies are often validated in models ranging from mammalian cell lines to knockout organisms to ensure specificity. Recent studies also explore STX7's involvement in infection mechanisms, as pathogens may exploit host trafficking machinery. Despite its established roles, ongoing research aims to clarify its regulatory mechanisms and tissue-specific functions, underscoring the antibody's continued relevance in cell biology and translational research.
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