| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | slp5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYTL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SYTL5抗体的3篇参考文献示例(注：内容基于假设性文献，实际引用时请核实真实来源)：
---
1. **标题**: "SYTL5 regulates insulin secretion through vesicle trafficking in pancreatic β-cells"
**作者**: Tanaka A, et al.
**摘要**: 本研究利用SYTL5特异性抗体，通过免疫荧光和Western blot技术，揭示了SYTL5在胰岛β细胞分泌囊泡运输中的关键作用，表明其通过Rab27A相互作用调控胰岛素释放，为糖尿病机制研究提供新视角。
2. **标题**: "Characterization of SYTL5 antibody for detecting exosome-associated protein complexes"
**作者**: Chen L, et al.
**摘要**: 该文献报道了一种新型SYTL5多克隆抗体的开发与验证，证明其在免疫共沉淀(Co-IP)和外泌体分离实验中的高效特异性，揭示了SYTL5在外泌体形成中的功能，为癌症生物标志物研究提供工具。
3. **标题**: "SYTL5 expression correlates with poor prognosis in gastric cancer: an immunohistochemical study"
**作者**: Kim S, et al.
**摘要**: 通过SYTL5抗体对胃癌组织进行免疫组化分析，发现SYTL5高表达与患者生存率降低显著相关，提示其可能作为肿瘤转移的潜在标志物，并参与调控Wnt信号通路。
---
**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文，并确保引用来源的准确性。若需具体文献支持，可提供更详细的研究背景或关键词进一步筛选。
The SYTL5 antibody targets Synaptotagmin-like protein 5 (SYTL5), a member of the synaptotagmin-related protein family. SYTL5 contains characteristic C2 domains and a Rab-binding motif, suggesting roles in membrane trafficking and vesicle transport. It is primarily studied for its interaction with Rab GTPases, which regulate intracellular vesicle formation, motility, and fusion. SYTL5 is implicated in secretory pathways, particularly in specialized cell types like endocrine or immune cells, though its precise biological functions remain under investigation.
Research links SYTL5 to cancer progression, with studies noting its overexpression in certain tumors, potentially influencing cell invasion or metastasis. It has also been associated with neurological disorders, possibly due to disrupted vesicle dynamics in synaptic transmission.
SYTL5 antibodies are essential tools for detecting protein expression, localization, and interaction partners via techniques like Western blot, immunofluorescence, or co-immunoprecipitation. Validation often includes verifying reactivity in knockdown models or tissue-specific expression patterns. Commercial SYTL5 antibodies vary in host species, clonality, and conjugation, requiring careful selection based on experimental needs. Challenges include ensuring specificity due to homology within the synaptotagmin-like family. Ongoing studies aim to clarify SYTL5's mechanistic roles and therapeutic potential in disease contexts.
×
