| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IGHG1; Ig gamma-1 chain C region |
| Entrez GeneID | 3500/3501/3502/3503 |
| WB Predicted band size | Calculated MW: 55,25 kDa; Observed MW: 55,25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Human IgG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SFTPA2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Surfactant Protein A2 (SFTPA2) Variants and Autoantibodies in Idiopathic Pulmonary Fibrosis*
**作者**：Wang, Y., et al.
**摘要**：该研究探讨了SFTPA2基因变异与特发性肺纤维化(IPF)的关联，通过特异性抗体检测发现患者血清中SFTPA2自身抗体水平升高，提示其可能作为IPF的生物标志物或参与疾病病理机制。
2. **文献名称**：*Structural and Functional Roles of Surfactant Protein A2 in Innate Immunity*
**作者**：Kishore, U., et al.
**摘要**：文章综述了SFTPA2在肺部先天免疫中的作用，包括其与病原体结合及调控炎症反应的功能，并提及使用特异性抗体解析SFTPA2蛋白结构域在宿主防御中的分子机制。
3. **文献名称**：*Autoantibodies Against SFTPA2 in Rheumatoid Arthritis-Associated Lung Disease*
**作者**：Murakami, S., et al.
**摘要**：研究发现类风湿关节炎合并间质性肺病患者体内存在针对SFTPA2的自身抗体，提示此类抗体可能参与肺组织损伤，为临床诊断和治疗提供了潜在靶点。
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注：以上文献为示例，实际引用时需核实具体来源及发表信息。
The surfactant protein A2 (SFTPA2) antibody is a tool used to detect and study SFTPA2. a critical component of pulmonary surfactant produced primarily by alveolar type II cells. SFTPA2 belongs to the collectin family, characterized by collagen-like regions and carbohydrate-recognition domains, and plays a dual role in lung homeostasis and innate immunity. It facilitates pathogen opsonization, enhances phagocytosis by alveolar macrophages, and modulates inflammatory responses. Mutations in the SFTPA2 gene are linked to familial pulmonary fibrosis and increased susceptibility to lung cancers, making it a focus in respiratory disease research.
SFTPA2 antibodies, either monoclonal or polyclonal, are utilized in techniques like Western blotting, immunohistochemistry, and ELISA to investigate SFTPA2 expression, localization, and function. These antibodies help identify abnormal SFTPA2 levels or structural variants in conditions such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and lung adenocarcinoma. Additionally, they aid in exploring SFTPA2's interaction with pathogens and its regulatory role in immune signaling pathways.
The development of SFTPA2 antibodies has advanced diagnostic and therapeutic research, offering potential as biomarkers for disease progression or targets for therapies aimed at modulating surfactant protein activity in lung disorders. Their specificity and reliability remain critical for understanding SFTPA2's contribution to lung pathology and immune regulation.
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