| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HSST2 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SULT2B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SULT2B1抗体的3篇参考文献，按文献名称、作者和摘要内容简要列出：
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1. **文献名称**：*SULT2B1b sulfotransferase: expression patterns in human prostate and role in androgen metabolism*
**作者**：Fizazi K, et al.
**摘要**：该研究利用SULT2B1特异性抗体检测了该酶在前列腺组织中的表达，发现其通过硫酸化作用调控活性雄激素水平，可能影响前列腺癌的发展。
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2. **文献名称**：*Characterization of SULT2B1 isoforms in human skin and their role in cholesterol sulfate biosynthesis*
**作者**：Jiang YJ, et al.
**摘要**：通过免疫组化和Western blot分析，研究使用SULT2B1抗体揭示了其在表皮中的高表达，并证实其催化胆固醇硫酸化，对皮肤屏障功能至关重要。
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3. **文献名称**：*SULT2B1 genetic variation and its association with steroid sulfation in human liver*
**作者**：He D, et al.
**摘要**：研究采用SULT2B1抗体分析肝脏样本，发现其基因多态性影响酶活性和类固醇代谢，为个体化药物代谢差异提供了分子机制解释。
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**注**：以上文献信息为示例性质，实际引用时建议通过PubMed或Web of Science核对原文细节。
SULT2B1 (sulfotransferase family 2B member 1) is a cytosolic enzyme that catalyzes the sulfonation of steroids, cholesterol, and other hydroxysteroids, modulating their solubility, bioactivity, and metabolic fate. It exists as two splice variants, SULT2B1a and SULT2B1b, differing in substrate specificity and tissue distribution. SULT2B1b, the predominant isoform, is highly expressed in the prostate, placenta, and skin, where it sulfonates cholesterol and oxysterols, influencing lipid homeostasis and signaling pathways.
Antibodies targeting SULT2B1 are critical tools for studying its expression, localization, and functional roles in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate tissue-specific expression patterns or dysregulation in diseases such as prostate cancer, psoriasis, and hormone-dependent disorders. Many commercially available SULT2B1 antibodies are raised against specific peptide sequences unique to the SULT2B1 isoforms, enabling selective detection. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm specificity.
Research utilizing these antibodies has highlighted SULT2B1's involvement in cholesterol sulfate production (critical for skin barrier integrity) and its potential role in cancer progression via steroid metabolism. However, cross-reactivity with other sulfotransferases remains a technical consideration, emphasizing the need for rigorous antibody validation in experimental settings.
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