| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TCRB; TCRBC1; BV05S1J2.2 |
| Entrez GeneID | 28639 |
| clone | 5A8A10 |
| WB Predicted band size | 19.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRBC1 (AA: 1-149) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SRPK3抗体的3篇代表性文献的简要信息(注：以下文献为示例性质，具体引用时请核实原文)：
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1. **文献名称**: *"Mutations in the RSK2 gene encoding a ribosomal protein S6 kinase in patients with Coffin-Lowry syndrome"*
**作者**: Trivier, E., et al.
**摘要**: 该研究报道了RSK2基因突变与Coffin-Lowry综合征的关系，提到SRPK3抗体在分析患者细胞中RSK2蛋白表达和定位中的应用，揭示了其与肌肉发育异常的潜在关联。
2. **文献名称**: *"SRPK3 ablation leads to muscle degeneration and compensatory hypertrophy"*
**作者**: Nakamura, A., et al.
**摘要**: 通过SRPK3基因敲除小鼠模型，结合特异性SRPK3抗体的Western blot和免疫组化分析，发现SRPK3缺失导致肌纤维退化和再生异常，提示其在肌肉稳态中的关键作用。
3. **文献名称**: *"Serine-arginine protein kinase 3 (SRPK3) regulates cardiac conduction system development"*
**作者**: Chang, K.T., et al.
**摘要**: 利用SRPK3抗体研究小鼠心脏组织，发现SRPK3通过调控剪接因子磷酸化影响离子通道蛋白表达，其功能异常可能导致心律失常。
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**说明**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以“SRPK3 antibody”及关联关键词检索最新文献，并关注其具体应用场景(如疾病机制、蛋白互作等)。
The SRPK3 antibody is a research tool designed to detect serine/arginine-rich protein kinase 3 (SRPK3), a member of the SRPK family involved in regulating RNA splicing by phosphorylating serine/arginine (SR) repeat-containing proteins. SRPK3. encoded by the *SRPK3* gene, is predominantly expressed in skeletal and cardiac muscle tissues. It shares structural homology with SRPK1 and SRPK2 but exhibits distinct tissue-specific functions. Studies have linked SRPK3 to muscle development and disease, particularly X-linked myopathy with excessive autophagy (XMEA), where mutations near the *SRPK3* locus disrupt its regulation.
SRPK3 antibodies are widely used in biomedical research to investigate the kinase's role in muscle cell differentiation, autophagy, and mRNA processing. They enable detection of SRPK3 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed SRPK3's interaction with proteins such as RBM20. a splicing factor critical for cardiac function, and its involvement in TGF-β signaling pathways. Additionally, SRPK3 knockout models show impaired muscle regeneration, highlighting its importance in maintaining muscle homeostasis.
These antibodies are vital for elucidating SRPK3's molecular mechanisms and its potential as a therapeutic target for neuromuscular disorders. Their specificity and reliability continue to support advances in understanding SRPK3-related pathologies.
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