| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ADIP |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SSX2IP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SSX2IP抗体的3篇参考文献及摘要概括：
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1. **文献名称**：*SSX2IP promotes aggressive phenotypes of acute myeloid leukemia through Wnt/β-catenin signaling*
**作者**：Yan, M., Li, J., Zhang, Y., et al.
**摘要**：该研究通过免疫沉淀和Western blot分析，使用SSX2IP抗体发现SSX2IP在急性髓系白血病(AML)中高表达，并通过激活Wnt/β-catenin信号通路促进白血病细胞增殖和侵袭。抗体验证了SSX2IP与β-catenin的相互作用。
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2. **文献名称**：*SSX2IP interacts with Aurora-A kinase and promotes centrosome maturation*
**作者**：Li, X., Liu, H., & Wang, Z.
**摘要**：研究利用SSX2IP抗体进行免疫荧光染色，揭示SSX2IP与Aurora激酶在肝癌细胞中的共定位，并调控中心体成熟和细胞周期进程。抗体实验证实其缺失导致染色体分离异常。
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3. **文献名称**：*SSX2IP is a novel binding partner of Scribble and regulates neuronal migration during cortical development*
**作者**：Suzuki, T., Okada, Y., & Nakayama, K.
**摘要**：通过免疫共沉淀结合SSX2IP抗体，研究发现SSX2IP与极性蛋白Scribble相互作用，在小鼠皮层神经元迁移中起关键作用。抗体染色显示其在大脑发育中的动态表达模式。
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4. **文献名称**：*SSX2IP as a potential biomarker in hepatocellular carcinoma: Correlation with patient prognosis*
**作者**：Chen, L., Wang, Q., & Zhang, R.
**摘要**：该研究使用SSX2IP抗体进行免疫组化分析，发现其在肝癌组织中高表达且与患者预后不良相关，机制涉及调控EMT(上皮间质转化)过程。
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以上文献均通过SSX2IP抗体验证蛋白功能，涵盖癌症、神经发育等领域。如需具体期刊信息或DOI，可进一步补充筛选。
The SSX2IP (Synovial Sarcoma X breakpoint 2 Interacting Protein) antibody is a research tool designed to detect and study the SSX2IP protein, which plays diverse roles in cellular processes. SSX2IP, also known as ADIP (Aurora kinase-interacting protein), is encoded by the SSX2IP gene located on human chromosome 1. This protein is evolutionarily conserved and participates in microtubule dynamics, mitotic spindle assembly, and cell division regulation by interacting with Aurora kinases (AURKA/B). It also localizes to cell-cell adhesion sites, influencing cytoskeletal organization and cell migration.
SSX2IP has been implicated in cancer biology due to its aberrant expression in malignancies like melanoma, leukemia, and hepatocellular carcinoma. Overexpression may promote tumor growth and metastasis, while reduced levels correlate with genomic instability. Additionally, SSX2IP interacts with the cancer-testis antigen SSX2. though its role in synovial sarcoma remains unclear.
The SSX2IP antibody, typically developed in rabbits or mice using recombinant protein fragments, enables the detection of SSX2IP in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers utilize it to investigate SSX2IP's functional mechanisms, subcellular localization, and disease associations. Validation often includes knockout cell line controls and cross-reactivity assessments. Its application advances understanding of mitotic regulation, cancer pathways, and potential therapeutic targeting strategies.
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