| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SEST3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SESN3抗体的参考文献示例(内容为虚构，仅作格式参考)：
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1. **文献名称**: "SESN3 modulates oxidative stress response in hepatocellular carcinoma via AMPK signaling"
**作者**: Li, X., Zhang, Y., & Wang, H.
**摘要**: 本研究通过Western blot和免疫组化技术，利用SESN3抗体检测肝癌细胞中SESN3蛋白的表达水平，发现其通过激活AMPK通路抑制ROS积累，进而影响肿瘤细胞增殖。
2. **文献名称**: "Sestrin3 regulates hepatic lipid metabolism through mTORC1 inhibition"
**作者**: Park, S., Kim, J., & Lee, D.
**摘要**: 文章采用SESN3特异性抗体分析小鼠肝脏组织，证实SESN3通过抑制mTORC1活性调控脂质代谢，为代谢综合征的治疗提供潜在靶点。
3. **文献名称**: "SESN3 deficiency exacerbates neuronal damage in Alzheimer's disease models"
**作者**: Chen, L., & Gupta, R.
**摘要**: 通过免疫荧光技术结合SESN3抗体，研究发现SESN3缺失会加剧β-淀粉样蛋白诱导的神经元氧化损伤，提示其在神经退行性疾病中的保护作用。
4. **文献名称**: "A novel role of SESN3 in autophagy regulation during skeletal muscle atrophy"
**作者**: Rossi, F., & Bonetto, A.
**摘要**: 利用SESN3抗体进行蛋白质印迹分析，揭示SESN3通过促进自噬途径缓解骨骼肌萎缩，为肌肉退行性病变机制研究提供新方向。
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注：以上文献信息均为模拟生成，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
SESN3 (Sestrin 3) is a member of the Sestrin family of stress-inducible proteins, which includes SESN1 and SESN2. These evolutionarily conserved proteins play critical roles in cellular stress responses, antioxidant defense, and metabolic regulation, primarily through modulation of AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) signaling pathways. SESN3 is less studied compared to SESN1/SESN2 but shares functional similarities, including involvement in oxidative stress resistance, maintenance of metabolic homeostasis, and potential links to aging-related processes. It is expressed in various tissues, with notable roles in liver metabolism and neuronal function.
SESN3 antibodies are essential tools for detecting and quantifying SESN3 protein levels in research applications such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help investigate SESN3's regulatory mechanisms in conditions like metabolic disorders, neurodegenerative diseases, and cancer. Studies suggest SESN3 may fine-tune mTORC1 activity in a context-dependent manner, influencing cell growth, autophagy, and energy balance. Its dysregulation has been implicated in insulin resistance, lipid accumulation, and oxidative damage. However, the precise molecular pathways and tissue-specific functions of SESN3 remain under exploration, driving the need for reliable antibody-based assays to advance its biological and therapeutic relevance.
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