| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PI8; CAP2 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERPINB8抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：
1. **文献名称**：*SERPINB8 regulates epidermal differentiation through protease inhibition*
**作者**：Hida S. et al.
**摘要**：该研究利用SERPINB8抗体在小鼠皮肤组织中进行免疫组化分析，发现SERPINB8通过抑制角质形成细胞中的丝氨酸蛋白酶活性，参与维持皮肤屏障功能及分化过程。
2. **文献名称**：*SERPINB8 suppresses tumor metastasis by inhibiting urokinase-type plasminogen activator*
**作者**：Buchholz T.A. et al.
**摘要**：文章通过Western blot和免疫荧光技术(使用SERPINB8抗体)证明，SERPINB8在乳腺癌细胞中高表达，并通过抑制尿激酶型纤溶酶原激活物(uPA)的活性，降低癌细胞侵袭能力。
3. **文献名称**：*SERPINB8 dysfunction links lysosomal leakage to neurodegeneration*
**作者**：Smith J. et al.
**摘要**：研究利用SERPINB8抗体进行共聚焦成像，发现SERPINB8缺失导致溶酶体膜稳定性下降，引发神经细胞凋亡，提示其在神经退行性疾病中的潜在作用。
(注：以上文献信息为示例性概括，实际引用需以真实发表的论文为准。)
SERPINB8. a member of the serine protease inhibitor (serpin) superfamily, plays a regulatory role in diverse cellular processes by inhibiting specific proteases. It is primarily known for its involvement in skin barrier maintenance, neuroprotection, and cancer progression. SERPINB8 inhibits enzymes like furin and cathepsin L, modulating proteolytic cascades critical for cellular homeostasis, differentiation, and apoptosis. Dysregulation of SERPINB8 has been linked to skin disorders (e.g., psoriasis), neurodegenerative diseases, and tumor metastasis, highlighting its pathophysiological relevance.
SERPINB8 antibodies are essential tools for studying its expression, localization, and function. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence to detect SERPINB8 in human, mouse, or rat tissues. They often target conserved epitopes within the reactive center loop (RCL), a key region mediating protease interaction. High-quality SERPINB8 antibodies enable researchers to explore its role in disease mechanisms, evaluate its diagnostic potential, or validate interactions with proteases in experimental models. Validation via knockout controls or peptide blocking ensures specificity, supporting reliable data in both basic research and clinical applications.
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