| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EI; LEI; PI2; MNEI; PI-2; HEL57; M/NEI; ELANH2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SERPINB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERPINB1抗体的3篇参考文献示例(内容基于公开研究概括，非真实文献)：
1. **文献名称**：*SERPINB1 regulates neutrophil survival and inflammatory response*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性SERPINB1抗体进行Western blot和流式细胞术分析，发现SERPINB1通过抑制caspase活性阻止中性粒细胞凋亡，其抗体在脓毒症模型中验证了蛋白表达与疾病严重程度的相关性。
2. **文献名称**：*Role of SERPINB1 in viral infection-induced lung injury*
**作者**：Chen L, et al.
**摘要**：通过免疫荧光和ELISA结合SERPINB1抗体，研究揭示SERPINB1在流感病毒感染中通过调节蛋白酶平衡减轻肺上皮细胞损伤，抗体检测显示其在感染后期表达显著上调。
3. **文献名称**：*SERPINB1 as a biomarker in non-small cell lung cancer*
**作者**：Wang Y, et al.
**摘要**：使用SERPINB1抗体进行免疫组化分析肺癌组织样本，发现高表达SERPINB1与患者生存率负相关，机制研究表明其通过抑制凋亡促进肿瘤细胞耐药性。
4. **文献名称**：*SERPINB1 deficiency exacerbates autoimmune arthritis in mice*
**作者**：Kimura T, et al.
**摘要**：在SERPINB1基因敲除小鼠中，通过抗体介导的蛋白质印迹和免疫沉淀技术，证实SERPINB1缺失导致关节滑膜炎症加剧，提示其抗炎功能依赖于对中性粒细胞蛋白酶的调控。
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注：以上为模拟内容，实际文献需通过数据库(如PubMed)检索确认。
SERPINB1. a member of the serine protease inhibitor (serpin) superfamily, is an intracellular protease inhibitor primarily expressed in immune cells, epithelial tissues, and certain cancer cells. It regulates proteolytic pathways by inhibiting neutrophil elastase, cathepsin G, and proteinase-3. enzymes involved in inflammation, tissue remodeling, and apoptosis. SERPINB1 plays a critical role in maintaining immune homeostasis, protecting tissues from protease-mediated damage during infections or inflammatory responses. Dysregulation of SERPINB1 has been linked to chronic inflammatory diseases, autoimmune disorders, and cancer progression.
SERPINB1 antibodies are essential tools for detecting and quantifying SERPINB1 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies enable the study of SERPINB1's spatial and temporal expression patterns, its interaction with proteases, and its role in disease mechanisms. Commercial SERPINB1 antibodies are typically developed using immunogenic peptide sequences or recombinant proteins, validated for specificity across human and murine models. Recent studies highlight SERPINB1's potential as a therapeutic target or biomarker, particularly in neutrophil-driven pathologies and cancer immunotherapy, driving demand for reliable antibodies to advance mechanistic and translational research.
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