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Rabbit Polyclonal RGS6 Antibody

  • 中文名: RGS6抗体
  • 别    名: GAP; S914; HA117
货号: IPDX01723
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/150-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与RGS6抗体应用相关的代表性文献示例(基于公开研究整理):

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1. **"RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated HDAC6 degradation and apoptosis"**

*作者:Stewart A, et al. (2015)*

**摘要**:本研究利用RGS6特异性抗体进行Western blot和免疫沉淀实验,发现RGS6通过促进Tip60依赖的HDAC6降解抑制Ras介导的细胞癌变,并证实RGS6缺失会增强肿瘤发生。

2. **"RGS6 as a Novel Modulator of Dopamine D2 Receptor-Dependent Signaling in Neuronal Cells"**

*作者:Yang J, et al. (2018)*

**摘要**:通过免疫荧光和共聚焦显微镜技术,作者使用RGS6抗体揭示其在多巴胺能神经元中的定位,证明RGS6负调控D2受体信号通路,可能影响神经精神疾病的病理机制。

3. **"RGS6 Mediates Cardiac Hypertrophy by Regulating G Protein-Coupled Receptor Kinase 2 (GRK2)"**

*作者:Wang L, et al. (2020)*

**摘要**:该研究通过心脏组织免疫组化结合RGS6抗体,发现RGS6通过抑制GRK2活性减轻病理性心脏肥大,为心力衰竭治疗提供新靶点。

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**注**:以上文献信息为示例性质,实际引用时建议通过PubMed或学术数据库核对具体作者、年份及摘要内容。

背景信息

The Regulator of G-protein Signaling 6 (RGS6) is a member of the RGS protein family, which negatively regulates G-protein-coupled receptor (GPCR) signaling by accelerating GTP hydrolysis on Gα subunits. RGS6 exists as multiple splice variants and contains a conserved RGS domain for Gα interaction and a GGL (G-protein γ-like) domain that enables dimerization with Gβ5. forming a complex critical for stability and function. It is broadly expressed in tissues, including the brain, heart, and cancer cells, and plays roles in neuronal development, oxidative stress response, and tumor suppression. Studies link RGS6 to diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. For instance, RGS6 acts as a tumor suppressor by promoting apoptosis and DNA repair in breast cancer, neuroblastoma, and other malignancies, while its dysfunction is implicated in Parkinson’s disease and heart failure.

RGS6 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies, often raised in rabbits or mice, target specific epitopes within RGS6 isoforms and are validated for applications like Western blotting, immunohistochemistry, and co-immunoprecipitation. High-quality RGS6 antibodies exhibit specificity confirmed by knockout controls or siRNA-mediated silencing. Researchers use them to explore RGS6’s tissue distribution, dynamic regulation under stress, and mechanisms in disease pathways. Challenges include distinguishing between splice variants and minimizing cross-reactivity with homologous RGS proteins. Overall, RGS6 antibodies advance understanding of its dual roles in cell survival and death, offering insights for therapeutic targeting in cancer and neurological disorders.

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