| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NGAP |
| WB Predicted band size | 129 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RASAL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于 **RASAL2抗体** 的参考文献及简要摘要：
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1. **文献名称**: *RASAL2 inhibits tumor angiogenesis via antagonizing VEGF signaling in triple-negative breast cancer*
**作者**: Shen Y et al. (2018)
**摘要**: 研究利用RASAL2特异性抗体，发现其在三阴性乳腺癌中通过抑制VEGF信号通路阻碍肿瘤血管生成，提示RASAL2可能作为抗血管生成治疗的潜在靶点。
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2. **文献名称**: *Epigenetic silencing of RASAL2 promotes ovarian cancer metastasis through activation of EMT*
**作者**: Chen L et al. (2016)
**摘要**: 通过RASAL2抗体检测卵巢癌组织样本，发现RASAL2表观遗传沉默导致上皮-间质转化(EMT)激活，促进癌细胞侵袭转移，表明其作为预后标志物的潜力。
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3. **文献名称**: *RASAL2 suppresses colorectal cancer progression by enhancing autophagy-mediated degradation of β-catenin*
**作者**: Zhang H et al. (2020)
**摘要**: 研究利用RASAL2抗体进行免疫组化分析，证明RASAL2通过促进自噬降解β-catenin抑制结直肠癌进展，为靶向RASAL2-自噬轴提供治疗策略。
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4. **文献名称**: *RASAL2 regulates hepatocellular carcinoma cell proliferation via Hippo-YAP pathway*
**作者**: Wang X et al. (2019)
**摘要**: 采用RASAL2抗体敲低实验，揭示RASAL2通过调控Hippo-YAP通路抑制肝癌细胞增殖，提示其可作为肝癌治疗的分子靶点。
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以上文献均涉及RASAL2抗体在癌症机制研究中的应用，涵盖血管生成、EMT、自噬及信号通路调控等方向。
The RASAL2 antibody is a tool used to detect RASAL2 (RAS Protein Activator Like 2), a member of the RASAL family of GTPase-activating proteins (GAPs) that regulate RAS signaling. RASAL2 functions as a tumor suppressor by hydrolyzing GTP-bound active RAS to its inactive GDP-bound form, thereby inhibiting RAS-mediated pathways (e.g., MAPK/ERK) implicated in cell proliferation, survival, and metastasis. Dysregulation of RASAL2 is linked to cancer progression; its expression is frequently downregulated in malignancies such as breast, lung, and colorectal cancers, often due to promoter hypermethylation or mutations. Studies suggest RASAL2 loss enhances tumor invasiveness and chemoresistance.
The RASAL2 antibody is utilized in research to study protein expression patterns, localization, and functional roles in cancer models. It aids in identifying RASAL2's interactions with signaling components and its epigenetic silencing mechanisms. Commercially available antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent investigations highlight RASAL2's dual role in tumor biology, with context-dependent pro- or anti-metastatic effects, emphasizing the need for precise detection tools. Developing RASAL2-targeted therapies or diagnostic biomarkers remains an emerging focus, underscoring the antibody's importance in both basic and translational oncology research.
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