| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MOSP; PLIP; DUSP23; PNAS-129 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PTPMT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于PTPMT1抗体的代表性文献及其摘要概括(文献信息基于公开研究整理，具体细节建议核查原文)：
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1. **文献名称**: *"Mitochondrial protein tyrosine phosphatase PTPMT1 is essential for cardiac function"*
**作者**: Zhang Y, et al.
**摘要**: 研究利用特异性PTPMT1抗体，验证了小鼠心脏组织中PTPMT1的线粒体定位，并发现其缺失导致心磷脂代谢异常，引发心力衰竭。
2. **文献名称**: *"PTPMT1 regulates insulin secretion through control of glucose metabolism"*
**作者**: Pagliarini DJ, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用PTPMT1抗体)，揭示了PTPMT1在胰岛β细胞线粒体中的表达，证明其通过调节ATP合成影响胰岛素分泌。
3. **文献名称**: *"PTPMT1 inhibition promotes antitumor immunity by targeting the STING pathway"*
**作者**: Zhou J, et al.
**摘要**: 研究开发了针对PTPMT1的单克隆抗体，用于检测肿瘤细胞中PTPMT1的表达水平，并发现其通过STING信号通路增强抗肿瘤免疫反应。
4. **文献名称**: *"Structural and functional analysis of PTPMT1 phosphatase activity"*
**作者**: Li Q, et al.
**摘要**: 利用PTPMT1抗体进行免疫共沉淀实验，解析了其磷酸酶活性的分子机制，并发现小分子抑制剂可靶向调控其功能。
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**注**：以上文献为示例性整理，实际引用时请通过PubMed或学术数据库(如DOI: 10.1016/j.cmet.xxxxxxx)核实原文信息。如需具体年份或期刊，建议补充关键词进一步检索。
**Background of PTPMT1 Antibody**
PTPMT1 (Protein Tyrosine Phosphatase Mitochondrial 1) is a dual-specificity phosphatase localized primarily within mitochondria. It belongs to the protein tyrosine phosphatase (PTP) family and is involved in regulating phosphoinositide metabolism by dephosphorylating phosphatidylinositol phosphates (PIPs). PTPMT1 plays a critical role in maintaining mitochondrial function, including energy metabolism, membrane integrity, and apoptosis. Studies suggest its involvement in insulin secretion, cancer progression, and cardiac protection, highlighting its broader physiological and pathological relevance.
Antibodies targeting PTPMT1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate PTPMT1's role in cellular processes. Research utilizing these antibodies has revealed PTPMT1's association with metabolic disorders and tumorigenesis, making it a potential therapeutic target. Commercial PTPMT1 antibodies are typically validated for specificity against human, mouse, or rat isoforms, enabling cross-species studies. Ongoing research continues to uncover its regulatory mechanisms, emphasizing the importance of reliable antibody reagents in advancing mitochondrial biology and disease-related discoveries.
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