| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RMD3; RMD-3; FAM82C; FAM82A2; ptpip51 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RMDN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于RMDN3抗体相关研究的示例参考文献(注：部分内容为模拟示例，实际文献需通过学术数据库核实)：
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1. **文献名称**: "RMDN3 regulates endoplasmic reticulum-associated degradation through interaction with VCP"
**作者**: Yamamoto S, et al.
**摘要**: 本研究利用兔源多克隆RMDN3抗体，揭示了RMDN3蛋白通过结合VCP(Vasolin-Containing Protein)调控内质网相关降解(ERAD)的分子机制。抗体验证包括免疫印迹和免疫共沉淀实验，证实其在HEK293细胞模型中的作用。
2. **文献名称**: "Development and characterization of a monoclonal antibody against human RMDN3 for diagnostic applications"
**作者**: Chen L, et al.
**摘要**: 报道了一种高特异性小鼠抗人RMDN3单克隆抗体的开发，应用于组织微阵列的免疫组化分析。结果显示RMDN3在乳腺癌组织中显著高表达，提示其作为潜在生物标志物的价值。
3. **文献名称**: "RMDN3 modulates mitochondrial dynamics via microtubule stabilization: Insights from CRISPR/Cas9 and antibody-based depletion"
**作者**: Müller R, et al.
**摘要**: 通过CRISPR/Cas9敲除结合抗RMDN3抗体的功能抑制实验，证明RMDN3通过稳定微管网络调控线粒体分裂/融合平衡。抗体用于活细胞成像，显示RMDN3在线粒体膜附近的定位。
4. **文献名称**: "Cross-species reactivity of anti-RMDN3 antibodies in neurodegenerative disease models"
**作者**: Park J, et al.
**摘要**: 评估了多种RMDN3抗体在小鼠、斑马鱼及人类脑组织中的交叉反应性，验证了抗体在阿尔茨海默病模型中的应用，发现RMDN3与tau蛋白病理相关。
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**建议**：实际引用时请通过PubMed或Google Scholar以关键词“RMDN3 antibody”或“RMDN3 + [研究领域]”检索最新文献，并关注高影响力期刊(如*Nature Cell Biology*, *Journal of Biological Chemistry*等)以获取可靠来源。
The RMDN3 (Regulating Mitochondrial Dynamics and Neurodegeneration 3) antibody is a tool used to study the RMDN3 protein, which plays a role in mitochondrial dynamics and cellular homeostasis. RMDN3. also known as CHCHD3 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3), is implicated in maintaining mitochondrial cristae structure and function, impacting energy production, apoptosis, and stress responses. Dysregulation of RMDN3 has been linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, due to its involvement in mitochondrial quality control and neuronal survival.
The RMDN3 antibody is primarily employed in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, localization, and interactions. It aids in exploring how RMDN3 modulates mitochondrial morphology, fusion-fission balance, and cross-talk with other organelles like the endoplasmic reticulum. Studies using this antibody have highlighted its relevance in cancer biology, where mitochondrial dysfunction contributes to tumor progression and therapy resistance. Additionally, it supports investigations into aging-related disorders and metabolic syndromes tied to mitochondrial impairment. Validated for specificity in human and rodent models, the RMDN3 antibody remains critical for deciphering mitochondrial mechanisms in health and disease.
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