Rabbit Polyclonal PPP2R3C Antibody

The PPP2R3C antibody targets the regulatory subunit B'' (also known as B56γ) of protein phosphatase 2A (PP2A), a critical serine/threonine phosphatase involved in diverse cellular processes. PPP2R3C encodes the gamma isoform of the B56 family, which directs PP2A’s substrate specificity and cellular localization. This subunit plays roles in cell cycle regulation, DNA damage response, and Wnt/β-catenin signaling by recruiting PP2A to dephosphorylate key targets like oncoproteins and tumor suppressors. Antibodies against PPP2R3C are essential tools for studying PP2A complex composition, activity, and dysfunction in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess expression levels, subcellular distribution, and interactions with partner proteins. Specificity of PPP2R3C antibodies is crucial due to high homology among B56 isoforms; many are developed using unique peptide sequences or recombinant proteins to minimize cross-reactivity. Validation often includes knockout cell lines or siRNA-mediated knockdown. Research leveraging these antibodies has highlighted PPP2R3C’s role in maintaining genomic stability and its potential as a therapeutic target, particularly in cancers with PP2A dysregulation. Reliable PPP2R3C antibodies thus support both mechanistic studies and clinical investigations into PP2A-related pathologies.