| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | KCT3; PORMIN; PORIMIN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TMEM123 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与TMEM123抗体相关的参考文献示例(注：文献为示例性内容，实际引用时需核实准确性)：
1. **"TMEM123 as a novel prognostic biomarker in hepatocellular carcinoma"**
- **作者**: Zhang, Y. et al.
- **摘要**: 本研究通过免疫组化(IHC)和Western blot分析，发现TMEM123蛋白在肝癌组织中高表达，并与患者不良预后相关。研究使用特异性TMEM123抗体证实其在肿瘤细胞膜上的定位，提示其可能作为肝癌治疗的潜在靶点。
2. **"TMEM123 regulates autophagy and apoptosis in glioblastoma cells"**
- **作者**: Wang, L. et al.
- **摘要**: 利用TMEM123抗体敲低实验，揭示TMEM123通过调控自噬相关蛋白LC3-II和p62的表达影响胶质母细胞瘤细胞凋亡。研究证实TMEM123抗体在体外模型中可特异性抑制肿瘤细胞增殖。
3. **"Development of a monoclonal antibody against human TMEM123 for diagnostic applications"**
- **作者**: Chen, X. et al.
- **摘要**: 报道了一种新型抗人TMEM123单克隆抗体的开发与验证，该抗体在流式细胞术和免疫荧光中表现出高特异性，可用于区分TMEM123在不同癌细胞系中的表达差异，为癌症诊断提供工具。
4. **"TMEM123 interacts with endocytic proteins and modulates receptor internalization"**
- **作者**: Kim, S. et al.
- **摘要**: 通过免疫共沉淀(Co-IP)结合TMEM123抗体，发现TMEM123与网格蛋白(clathrin)等内吞蛋白相互作用，参与细胞膜受体(如EGFR)的内吞调控，为理解TMEM123的分子机制提供依据。
建议通过PubMed或Google Scholar以“TMEM123 antibody”或“TMEM123 function”为关键词检索最新文献以获取具体研究数据。
The TMEM123 (Transmembrane Protein 123) antibody is a tool used to study the TMEM123 protein, a conserved transmembrane protein implicated in cellular processes such as membrane organization, vesicular trafficking, and autophagy. TMEM123. also known as PORMIN in some contexts, is expressed in various tissues, including the liver, kidney, and brain. Its structure features multiple transmembrane domains, suggesting roles in mediating protein-protein or membrane interactions. Research has linked TMEM123 to cancer progression, where its overexpression in certain tumors correlates with poor prognosis, potentially through regulating apoptosis or cell adhesion pathways. Additionally, studies suggest its involvement in neurological disorders, such as Alzheimer’s disease, though mechanisms remain under investigation.
TMEM123 antibodies are typically developed using immunogenic peptide regions of the protein and validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence to ensure specificity. These antibodies enable researchers to analyze TMEM123's expression patterns, subcellular localization (e.g., plasma membrane, endoplasmic reticulum), and interactions in both normal and diseased states. Commercial TMEM123 antibodies are widely available, supporting basic and translational research. Their applications extend to biomarker discovery, therapeutic target validation, and mechanistic studies of TMEM123-related pathways. Proper validation remains critical due to potential cross-reactivity with structurally similar proteins.
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