| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CLIM1; CLP36; CLP-36; hCLIM1; HEL-S-112 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PDLIM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PDLIM1抗体的参考文献示例(文献信息为虚构，仅供参考格式)：
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1. **文献名称**：PDLIM1 suppresses epithelial-mesenchymal transition in breast cancer through TGF-β/Smad signaling regulation
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用PDLIM1特异性抗体进行Western blot和免疫组化分析，发现PDLIM1通过抑制TGF-β/Smad信号通路阻止乳腺癌细胞的EMT进程，提示其作为肿瘤转移抑制因子的潜在作用。
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2. **文献名称**：PDLIM1 modulates nuclear factor-κB activity in inflammatory responses
**作者**：Kim S, Tanaka H, et al.
**摘要**：通过免疫共沉淀和免疫荧光技术(使用PDLIM1抗体)，研究发现PDLIM1通过与NF-κB p65亚基相互作用，负调控炎症反应中NF-κB的活化，为炎症性疾病治疗提供新靶点。
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3. **文献名称**：Aberrant PDLIM1 expression correlates with colorectal cancer progression
**作者**：Gupta R, et al.
**摘要**：采用PDLIM1抗体对结直肠癌组织进行免疫组化染色，发现PDLIM1低表达与肿瘤分期、转移及患者生存率显著相关，表明其可作为预后生物标志物。
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**备注**：以上文献为示例，实际研究中建议通过PubMed、Web of Science等数据库检索真实文献(关键词：PDLIM1 antibody, PDLIM1 function)。
**Background of PDLIM1 Antibody**
PDLIM1 (PDZ and LIM domain protein 1), also known as CLP-36 or CLIM1. is a cytoskeletal protein belonging to the PDZ-LIM family, characterized by its N-terminal PDZ domain and C-terminal LIM domain. It plays critical roles in cell adhesion, cytoskeletal organization, and signal transduction by interacting with actin-associated proteins, transcription factors, and signaling molecules. PDLIM1 is involved in regulating nuclear translocation of transcription factors like NF-κB and STAT, linking cytoskeletal dynamics to gene expression. Dysregulation of PDLIM1 has been implicated in cancer, inflammation, and cardiovascular diseases, with studies highlighting its dual roles as a tumor suppressor or promoter depending on context.
The PDLIM1 antibody is a vital tool for detecting and quantifying PDLIM1 expression in cells and tissues. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study its localization, protein-protein interactions, and functional mechanisms. Researchers employ this antibody to explore PDLIM1’s involvement in cellular processes, disease pathways, and therapeutic targeting. Validated for specificity and sensitivity, it aids in distinguishing PDLIM1 isoforms and post-translational modifications, providing insights into its context-dependent roles in health and disease. Commercial antibodies are typically raised in hosts like rabbits or mice, with clonal variants (monoclonal/polyoclonal) optimized for diverse experimental needs.
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