Rabbit Polyclonal OTUB2 Antibody

The OTUB2 antibody is a crucial tool for studying the deubiquitinating enzyme OTUB2. a member of the ovarian tumor (OTU) protease subfamily within the deubiquitinase (DUB) family. OTUB2 regulates protein stability and signaling pathways by cleaving ubiquitin chains from substrate proteins, thereby modulating processes like DNA repair, cell cycle progression, and immune responses. Unlike its homolog OTUB1. OTUB2 exhibits distinct substrate preferences and regulatory mechanisms, often functioning through non-catalytic interactions. For example, OTUB2 can stabilize the oncoprotein c-MYC by blocking its ubiquitination, linking it to cancer progression. Researchers use OTUB2 antibodies in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions in cellular contexts. Studies have implicated OTUB2 in diseases like glioblastoma, breast cancer, and neurodegenerative disorders, highlighting its therapeutic potential. The antibody’s specificity ensures accurate detection of OTUB2 isoforms and post-translational modifications, which are critical for understanding its dual roles in promoting or suppressing tumors depending on cellular context. Ongoing research aims to clarify its regulatory networks and explore OTUB2-targeted therapies, making this antibody indispensable for both basic and translational studies in oncology and beyond.