| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human OCIAD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OCIAD2抗体的3篇参考文献的简要信息(注：文献为虚构示例，仅供格式参考)：
1. **文献名称**：*"OCIAD2 Expression Correlates with Ovarian Cancer Progression and Chemoresistance"*
**作者**：Chen, L., et al.
**摘要**：该研究通过免疫组化(使用OCIAD2抗体)分析了卵巢癌组织中OCIAD2的表达水平，发现其高表达与肿瘤分期进展和化疗耐药性显著相关，提示OCIAD2可能作为预后评估的潜在标志物。
2. **文献名称**：*"Mitochondrial Localization and Functional Role of OCIAD2 in Cellular Metabolism"*
**作者**：Tanaka, K., et al.
**摘要**：利用OCIAD2抗体进行Western blot和免疫荧光实验，揭示了OCIAD2在线粒体中的定位，并证明其通过调控复合物III的稳定性影响线粒体呼吸链功能，进而促进癌细胞能量代谢。
3. **文献名称**：*"OCIAD2 as a Novel Therapeutic Target in Triple-Negative Breast Cancer"*
**作者**：Patel, R., et al.
**摘要**：研究通过抗体介导的OCIAD2敲降实验，发现抑制OCIAD2可显著减少三阴性乳腺癌细胞的侵袭和转移能力，其机制可能与EGFR信号通路相互作用有关，为靶向治疗提供了依据。
The OCIAD2 (Ovarian Carcinoma Immunoreactive Antigen Domain Containing 2) gene encodes a mitochondrial membrane-associated protein implicated in cellular energy metabolism and mitochondrial function. Initially identified in ovarian cancer studies, OCIAD2 is broadly expressed across tissues and localizes to mitochondrion-associated membranes (MAMs), critical sites for regulating lipid metabolism, calcium signaling, and apoptosis. Its role in mitochondrial dynamics and inter-organelle communication suggests involvement in cellular stress responses and homeostasis.
OCIAD2 has been linked to cancer progression, particularly in ovarian, lung, and colorectal cancers, where overexpression correlates with tumor aggressiveness, metastasis, and poor prognosis. It may promote survival pathways by modulating mitochondrial apoptosis or interacting with oncogenic signaling networks. Recent studies also highlight its potential association with neurodegenerative disorders, such as Alzheimer’s disease, possibly through mitochondrial dysfunction.
Antibodies targeting OCIAD2 are essential tools for detecting its expression and localization in cells or tissues. They enable research into its molecular mechanisms, diagnostic applications, and therapeutic targeting. However, challenges remain in validating antibody specificity due to OCIAD2’s structural homology with OCIAD1 and cross-reactivity risks. Ongoing studies aim to clarify its dual roles in cancer and neurodegeneration, positioning OCIAD2 as a multifaceted protein with translational research significance.
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