| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Rd9; NIR2; RDGB; DRES9; RDGB1; RDGBA; PITPNM; RDGBA1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PITPNM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PITPNM1抗体的3篇代表性文献(模拟整理，仅供参考)：
1. **文献名称**：*PITPNM1 promotes cell migration in breast cancer via calcium signaling*
**作者**：Zhang Y, et al.
**摘要**：本研究利用PITPNM1特异性抗体进行Western blot和免疫荧光实验，发现其在乳腺癌细胞中高表达，并通过调控钙离子信号通路促进肿瘤细胞迁移。抗体验证表明，PITPNM1与细胞伪足形成相关。
2. **文献名称**：*Interaction of PITPNM1 with Tau protein in Alzheimer’s disease models*
**作者**：Wang L, et al.
**摘要**：通过免疫共沉淀(使用PITPNM1抗体)和共定位分析，发现PITPNM1与病理性Tau蛋白在阿尔茨海默病模型中存在相互作用，提示其可能参与神经纤维缠结的形成。
3. **文献名称**：*PITPNM1 as a prognostic marker in colorectal cancer*
**作者**：Tanaka K, et al.
**摘要**：采用PITPNM1抗体对结直肠癌组织进行免疫组化染色，发现高表达患者预后较差。研究证实PITPNM1通过PI3K/AKT通路影响肿瘤侵袭性，抗体特异性经敲除实验验证。
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**注**：以上文献为示例性质，实际引用需根据具体研究通过学术数据库核实。建议在PubMed或Web of Science中以“PITPNM1 antibody”或“PITPNM1 immunohistochemistry”为关键词检索最新研究。
The PITPNM1 antibody targets the PITPNM1 protein, a member of the membrane-associated phosphatidylinositol transfer protein (PITPNM) family. PITPNM1. also known as RDGBα or PYK2 N-terminal domain-interacting receptor, plays a critical role in intracellular lipid transport and signaling. It contains an N-terminal phosphatidylinositol transfer domain (PITP) and C-terminal repetitive domains, facilitating interactions with membranes and signaling molecules. PITPNM1 regulates phosphoinositide homeostasis, impacting processes like vesicular trafficking, cytoskeletal reorganization, and cell migration. Dysregulation of PITPNM1 is linked to cancer metastasis, neurodegenerative disorders, and metabolic diseases.
Antibodies against PITPNM1 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in cellular pathways. Research highlights its involvement in growth factor signaling (e.g., EGFR, PDGFR) and interactions with Rho GTPases, influencing Golgi structure and cell motility. PITPNM1 antibodies also aid in exploring its potential as a biomarker or therapeutic target in diseases characterized by aberrant lipid signaling or membrane dynamics. Validated antibodies are critical for distinguishing PITPNM1 from homologous family members (PITPNM2/3) due to structural similarities. These reagents support ongoing studies in cancer biology, neurobiology, and metabolic regulation.
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