| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human JCHAIN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NECTIN3抗体的3篇参考文献示例(基于公开信息概括，非真实文献，仅供格式参考)：
1. **"Nectin-3 expression correlates with poor prognosis in ovarian cancer"**
*作者：Smith A, et al. (2020)*
**摘要**：研究通过免疫组化分析发现，NECTIN3在卵巢癌组织中高表达，且与肿瘤转移和患者生存率降低显著相关，提示其可能作为预后标志物。
2. **"Nectin-3 antibody blocks measles virus entry in vitro"**
*作者：Jones R, et al. (2018)*
**摘要**：实验表明，针对NECTIN3的单克隆抗体可通过抑制病毒与宿主细胞结合，有效阻断麻疹病毒的体外感染，为抗病毒治疗提供新策略。
3. **"Nectin-3 deficiency alters synaptic plasticity in a mouse model of autism"**
*作者：Chen L, et al. (2021)*
**摘要**：利用NECTIN3抗体敲除小鼠模型，研究发现NECTIN3缺失导致海马区突触功能异常，可能与自闭症谱系障碍的病理机制相关。
4. **"Targeting Nectin-3 enhances chemotherapy sensitivity in gastric cancer"**
*作者：Wang Y, et al. (2019)*
**摘要**：通过体内实验证明，联合使用NECTIN3抗体与化疗药物可显著抑制胃癌细胞增殖，机制涉及调控EGFR信号通路。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索确认。)
Nectin-3. a member of the Nectin family of cell adhesion molecules, plays a critical role in mediating cell-cell adhesion and signaling. As part of the immunoglobulin superfamily, it contains three extracellular immunoglobulin-like domains that facilitate homophilic or heterophilic interactions, notably with Nectin-1. These interactions are essential for forming adherens junctions and tight junctions, often cooperating with cadherins and afadin to regulate tissue architecture, polarity, and morphogenesis. Nectin-3 is widely expressed in epithelial, neuronal, and immune cells, contributing to processes like synaptic plasticity, immune response modulation, and pathogen entry (e.g., herpesviruses).
Nectin-3 antibodies are immunological tools designed to detect, quantify, or inhibit this protein in research and clinical settings. They are commonly used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to study Nectin-3's expression patterns and localization. Dysregulation of Nectin-3 has been implicated in pathologies, including cancer, neurological disorders, and infertility. For instance, reduced Nectin-3 expression correlates with poor prognosis in ovarian and lung cancers, while its overexpression may enhance tumor invasiveness. Antibodies targeting Nectin-3 also hold therapeutic potential, such as blocking viral entry or modulating immune checkpoints.
These antibodies are typically validated for specificity, sensitivity, and cross-reactivity across species. Both monoclonal and polyclonal variants are available, with applications spanning basic research to drug development. Ongoing studies explore their utility in biomarker discovery and targeted therapies, underscoring Nectin-3's multifaceted role in health and disease.
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